所有图片(1)
About This Item
经验公式（希尔记法）:
C19H12N3OCl3S
CAS号:
分子量:
436.74
MDL號碼:
分類程式碼代碼:
12352203
PubChem物質ID:
NACRES:
NA.77
推荐产品
化驗
≥98% (HPLC)
形狀
solid
儲存條件
desiccated
溶解度
DMSO: soluble 28 mg/mL
H2O: insoluble
儲存溫度
−20°C
SMILES 字串
Clc1ccc(cc1)-c2nc3sccn3c2\C=N\OCc4ccc(Cl)c(Cl)c4
InChI
1S/C19H12Cl3N3OS/c20-14-4-2-13(3-5-14)18-17(25-7-8-27-19(25)24-18)10-23-26-11-12-1-6-15(21)16(22)9-12/h1-10H,11H2/b23-10+
InChI 密鑰
ZQWBOKJVVYNKTL-AUEPDCJTSA-N
一般說明
CITCO是一种咪唑并噻唑衍生物。它刺激人类组成型雄烷受体（CAR）核易位。
應用
CITCO已用于小鼠组成型雄烷受体（CAR）和人CAR的激活。
生化／生理作用
CITCO是组成型雄烷受体（CAR）激动剂；核受体NR113激动剂。
訊號詞
Warning
危險聲明
危險分類
Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
標靶器官
Respiratory system
儲存類別代碼
11 - Combustible Solids
水污染物質分類（WGK）
WGK 3
閃點（°F）
Not applicable
閃點（°C）
Not applicable
個人防護裝備
dust mask type N95 (US), Eyeshields, Gloves
其他客户在看
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Clinical pharmacology in drug development, 6(5), 466-475 (2017-03-17)
Tenapanor (RDX5791, AZD1722) is an inhibitor of sodium/hydrogen exchanger isoform 3 in development for the treatment of constipation-predominant irritable bowel syndrome and the treatment of hyperphosphatemia in patients with chronic kidney disease on dialysis. We aimed to investigate whether tenapanor
Constitutive androstane receptor agonist CITCO inhibits growth and expansion of brain tumour stem cells
Chakraborty S , et al.
British Journal of Cancer, 104(3), 448-448 (2011)
Constitutive androstane receptor (Car)-driven regeneration protects liver from failure following tissue loss
Tschuor C, et l.
Journal of Hepatology, 65(1), 66-74 (2016)
Congrong Niu et al.
Frontiers in pharmacology, 11, 620197-620197 (2021-02-09)
The induction potentials of ligand-activated nuclear receptors on metabolizing enzyme genes are routinely tested for new chemical entities. However, regulations of drug transporter genes by the nuclear receptor ligands are underappreciated, especially in differentiated human hepatocyte cultures. In this study
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