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品質等級
化驗
≥98% (HPLC)
形狀
powder
儲存條件
desiccated
顏色
white
溶解度
DMSO: ≥20 mg/mL
起源
GlaxoSmithKline
SMILES 字串
Cl[H].OC(=O)Cc1cccc(OCCCN(CC(c2ccccc2)c3ccccc3)Cc4cccc(c4Cl)C(F)(F)F)c1
InChI
1S/C33H31ClF3NO3.ClH/c34-32-27(15-8-17-30(32)33(35,36)37)22-38(18-9-19-41-28-16-7-10-24(20-28)21-31(39)40)23-29(25-11-3-1-4-12-25)26-13-5-2-6-14-26;/h1-8,10-17,20,29H,9,18-19,21-23H2,(H,39,40);1H
InChI 密鑰
NMPUWJFHNOUNQU-UHFFFAOYSA-N
生化／生理作用
GW3965是hLXRα和hLXRβ上的肝X受体完全激动剂。 在 LXRα 的无细胞配体感应测定中，GW3965 具有 EC 50 = 125 nM和并且在在基于细胞的测定中作为hLXRα和hLXRβ的完全激动剂分布， EC 50 = 190 nM 和 30 nM 。在小鼠中具有口服活性。当针对一组核受体进行筛选时，它只与孕烷 X 受体 (PXR) 发生交叉反应。文献激动剂 T0901317 (Tularik) 在无细胞和基于细胞的测定分别有 EC 50 = 60 nM 和 85 nM。
特點和優勢
该化合物由GlaxoSmithKline开发。要浏览其他药物开发化合物和批准的药物/候选药物列表，单击此处。
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訊號詞
Danger
危險分類
Acute Tox. 4 Oral - Aquatic Chronic 4 - Eye Dam. 1
儲存類別代碼
11 - Combustible Solids
水污染物質分類（WGK）
WGK 3
閃點（°F）
Not applicable
閃點（°C）
Not applicable
個人防護裝備
dust mask type N95 (US), Eyeshields, Gloves
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