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化驗
≥95% (SDS-PAGE)
形狀
aqueous glycerol solution
比活性
≥1000 U/mg
UniProt登錄號
運輸包裝
dry ice
儲存溫度
−70°C
基因資訊
human ... CAPN1(823)
應用
人类钙蛋白酶 1 已用在一项研究中评估人类钙蛋白酶 1 和 9 的晶体结构是如何暗示各种作用和自抑制机制的。人钙蛋白酶 1 也已用于研究 N 杂环二肽醛（作为选择性钙蛋白酶抑制剂）的合成、生物学评估和分子模型研究。
生化／生理作用
胞质蛋白酶作为上游调节剂参与细胞骨架重塑、自噬和细胞凋亡。
钙蛋白酶 1 是含有 EF 手基序的中性钙依赖性半胱氨酸蛋白酶。蛋白酶由两个亚基组成；较大的亚基具有四个与木瓜蛋白酶和钙调蛋白同源的结构域。较小的亚基具有一个与钙调蛋白具有同源性的结构域。它被微摩尔水平的钙激活，因此也被称为微钙蛋白酶。它的激活导致细胞蛋白降解、神经元细胞变性和自身免疫性脱髓鞘疾病，例如多发性硬化。
物理性質
钙蛋白酶 1 是异二聚体钙激活的巯基蛋白酶。
單位定義
在25 °C 下，每分钟一个单位水解1皮摩尔的Suc-LLVY-AMC。
外觀
在 20 mM 咪唑-HCl，5 mM β-巯基乙醇，1 mM EDTA，1 mM EGTA 和 30％ 甘油中的溶液。
抑制劑
产品编号
说明
价格
儲存類別代碼
10 - Combustible liquids
水污染物質分類（WGK）
WGK 1
閃點（°F）
Not applicable
閃點（°C）
Not applicable
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Huntington's disease (HD) is an autosomal dominant, late-onset neurodegenerative disorder characterized by a selective neuronal cell death in the cortex and striatum leading to cognitive dysfunction, motor impairment and behavioral changes.
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