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品質等級
化驗
≥98% (HPLC)
形狀
powder
光學活性
[α]/D -80 to -99°, c = 0.5 in chloroform-d
儲存條件
desiccated
protect from light
顏色
orange-brown
溶解度
DMSO: ≥5 mg/mL
應用
metabolomics
vitamins, nutraceuticals, and natural products
儲存溫度
2-8°C
SMILES 字串
C[C@H]1COC2=C1C(=O)C(=O)c3c4CCCC(C)(C)c4ccc23
InChI
1S/C19H20O3/c1-10-9-22-18-12-6-7-13-11(5-4-8-19(13,2)3)15(12)17(21)16(20)14(10)18/h6-7,10H,4-5,8-9H2,1-3H3/t10-/m0/s1
InChI 密鑰
GVKKJJOMQCNPGB-JTQLQIEISA-N
生化／生理作用
隐丹参酮是一种从亚洲药用植物丹参的根中分离出的醌类二萜。最新研究表明，该化合物是有效的 STAT3 抑制剂。隐丹参酮通过 JAK2 非依赖性机制快速抑制 STAT3 Tyr705 磷酸化。隐丹参酮通过与单体 STAT3 结合选择性抑制 STAT3 活化的细胞系，随后阻断二聚化并抑制 STAT3 转录调节活性。以前，研究据报道了该化合物通过抑制环加氧酶 II 活性和内皮素-1 的表达来消除炎症。丹参（Danshen）的干根在传统的东方医学中通常用于治疗循环障碍、肝病、冠心病、肝炎和慢性肾衰竭。
儲存類別代碼
13 - Non Combustible Solids
水污染物質分類（WGK）
WGK 3
閃點（°F）
Not applicable
閃點（°C）
Not applicable
其他客户在看
Fu-Lin Zheng et al.
Chinese medical journal, 124(24), 4293-4298 (2012-02-22)
Cryptotanshinone (CT) is the major active constituent of Salvia miltiorrhiza Bunge. The present study was carried out to investigate the effects of CT on rats with adjuvant arthritis (AA). AA was induced by the metatarsal footpad injection with complete Freund's
Shuangtao Ma et al.
Molecular medicine reports, 6(1), 145-150 (2012-04-17)
Cryptotanshinone is an active ingredient of Salvia miltiorrhiza that has been used in traditional Chinese medicine for treating cardiovascular disorders. Thus, we investigated the effects of cryptotanshinone on cardiac fibrosis induced by isoprenaline and examined whether cardiac matrix metalloproteinase (MMP)-2
Wenxing Chen et al.
Cancer prevention research (Philadelphia, Pa.), 5(5), 778-787 (2012-04-12)
Cryptotanshinone (CPT), a natural compound isolated from the plant Salvia miltiorrhiza Bunge, is a potential anticancer agent. However, the underlying mechanism is not well understood. Here, we show that CPT induced caspase-independent cell death in human tumor cells (Rh30, DU145
Wentao Bi et al.
Talanta, 85(1), 701-706 (2011-06-08)
Ionic liquid-based extraction of medicinal or useful compounds from plants was investigated as an alternative to supercritical fluid, cloud point and conventional organic solvent extractions. The method integrated extraction and preconcentration. Medicinal products were first extracted by an ionic liquid
Yingjie Wei et al.
Molecules (Basel, Switzerland), 17(7), 8617-8632 (2012-07-20)
The study aimed to investigate the potential of zebrafish in imitating mammal phase I metabolism of natural compounds. Three diterpenoid quinones from Radix Salvia miltiorrhiza, namely tanshinone IIA (TIIA), cryptotanshinone (Cry) and tanshinone I (TI) were selected as model compounds
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