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重組細胞
expressed in insect cells Active recombinant N-terminal His-tagged COX-2 N580A mutant purified from insect cells.
expressed in insect cells
品質等級
化驗
≥70% (SDS-PAGE)
形狀
aqueous solution
比活性
≥8000 units/mg protein
分子量
dimer subunit mol wt 70-74 kDa
UniProt登錄號
運輸包裝
dry ice
儲存溫度
−70°C
基因資訊
human ... PTGS2(5743)
生化／生理作用
COX-2 催化花生四烯酸转化为前列腺素 H 2 （前列腺素、血栓素和前列环素生物合成的第一步）。它是由佛波醇酯，脂多糖和细胞因子诱导的诱导形式的环加氧酶。COX-2 在恶性肿瘤的新生血管中表达上调。非甾体抗炎药 (NSAIDs) 抑制 COX-2 与肿瘤生长减少有关。
其他說明
在 N 端附近标记 6 个残基的组氨酸序列。
單位定義
在 37℃、pH 值为 8 的条件下，一个单位每分钟消耗 1.0 纳摩尔氧气。
外觀
80mm Tris溶液，pH 8.0，含0.3 mM DDC、0.01% TWEEN® 20和10%甘油
基底
花生四烯酸的 KM = 6.5 μM。表现出与非标记酶相似的 NSAID 活性和敏感性。
法律資訊
TWEEN is a registered trademark of Croda International PLC
儲存類別代碼
10 - Combustible liquids
水污染物質分類（WGK）
WGK 1
閃點（°F）
Not applicable
閃點（°C）
Not applicable
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