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About This Item
经验公式（希尔记法）:
C8H16ClNO2 · HCl
CAS号:
分子量:
230.13
MDL號碼:
分類程式碼代碼:
12352200
PubChem物質ID:
NACRES:
NA.77
推荐产品
品質等級
化驗
>97% (GC)
形狀
powder
儲存條件
desiccated
顏色
white
mp
78-81 °C
溶解度
H2O: >5 mg/mL
ethanol: soluble
methanol: soluble
儲存溫度
−20°C
SMILES 字串
Cl[H].CCN(CCCl)CCOC(C)=O
InChI
1S/C8H16ClNO2.ClH/c1-3-10(5-4-9)6-7-12-8(2)11;/h3-7H2,1-2H3;1H
InChI 密鑰
CHWPASAPXMNLKO-UHFFFAOYSA-N
應用
Acetylethylcholine mustard hydrochloride has been used as a precursor in ethylcholine aziridinium (AF64A) preparation. It has also been used in the pharmacokinetic study to investigate its role in neuromuscular junction (NMJ) signal transmission and function.
生化／生理作用
Acetylethylcholine mustard hydrochloride can reduce the contraction frequency of the myotubes by inhibiting the synthesis of acetylethylcholine (Ach) with the half-maximal inhibitory concentration (IC50) of 1.22 mM.
Acetylethylcholine mustard is a precursor for ethylcholine mustard aziridinium ion (AF-64A); irreversible ligand for the high affinity choline transport system; specific presynaptic long action cholinotoxin; inhibitor of choline acetyl-transferase.
注意
Extremely hygroscopic.
訊號詞
Danger
危險分類
Acute Tox. 2 Dermal - Acute Tox. 2 Inhalation - Acute Tox. 2 Oral - Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 1 - STOT SE 3
標靶器官
Nervous system, Respiratory system
儲存類別代碼
6.1A - Combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials
水污染物質分類（WGK）
WGK 3
閃點（°F）
204.8 °F - closed cup
閃點（°C）
96 °C - closed cup
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Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association, 48(3), 798-802 (2009-12-26)
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