跳转至内容
Merck
所有图片(1)

主要文件

查看所有文档

B7561

Sigma-Aldrich

1(S),9(R)-(−)-甲基溴化荷包牡丹碱

≥98% (HPLC), solid

别名:

(5S)-5-[(6R)-6,8-Dihydro-8-oxofuro[3,4-e]-1,3-benzodioxol-6-yl]-5,6,7,8-tetrahydro-6,6-dimethyl-1,3-dioxolo[4,5-g]isoquinolinium bromide (1:1)

登录查看公司和协议定价
所有图片(1)

About This Item

经验公式（希尔记法）:
C21H20BrNO6
CAS号:
66016-70-4
分子量:
462.29
MDL號碼:
MFCD00055149
分類程式碼代碼:
12352200
PubChem物質ID:
329773298
NACRES:
NA.77

品質等級

100

化驗

≥98% (HPLC)

形狀

solid

顏色

white to off-white

溶解度

H2O: >10 mg/mL

儲存溫度

2-8°C

SMILES 字串

[Br-].C[N+]1(C)CCc2cc3OCOc3cc2[C@H]1[C@@H]4OC(=O)c5c6OCOc6ccc45

InChI

1S/C21H20NO6.BrH/c1-22(2)6-5-11-7-15-16(26-9-25-15)8-13(11)18(22)19-12-3-4-14-20(27-10-24-14)17(12)21(23)28-19;/h3-4,7-8,18-19H,5-6,9-10H2,1-2H3;1H/q+1;/p-1/t18-,19+;/m0./s1

InChI 密鑰

BWXCECYGGMGBHD-GRTNUQQKSA-M

正在寻找类似产品? 访问 产品对比指南

應用

1(S),9(R)-(-)-Bicuculline methbromide has been used:
  • as a γ-aminobutyric acid (GABAA) receptor A antagonist: in cortical neuron culture
  • in artificial cerebrospinal fluid (ACSF) formature dentate granule neurons
  • in hypothalamic explant cultures

生化／生理作用

1(S),9(R)-(−)-Bicuculline methbromide is a GABAA receptor antagonist, which blocks Ca2+-activated potassium (SK) channels. It is the water-soluble derivative of (+)-bicuculline.

特點和優勢

This compound is a featured product for Neuroscience research. Click here to discover more featured Neuroscience products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.

象形圖

Skull and crossbonesEnvironment
GHS06,GHS09

訊號詞

Danger

危險分類

Acute Tox. 1 Oral - Acute Tox. 3 Dermal - Acute Tox. 3 Inhalation - Aquatic Acute 1 - Aquatic Chronic 1

儲存類別代碼

6.1A - Combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials

水污染物質分類（WGK）

WGK 3

閃點（°F）

Not applicable

閃點（°C）

Not applicable

個人防護裝備

Eyeshields, Gloves, type N95 (US)

从最新的版本中选择一种：

分析证书(COA)

Lot/Batch Number
102M4621V
038K46044
038K46043
038K46042
038K46041

没有发现合适的版本？

如果您需要特殊版本，可通过批号或批次号查找具体证书。

搜索COA

已有该产品？

在文件库中查找您最近购买产品的文档。

访问文档库

其他客户在看

Slide 1 of 2

1 of 2

4-氨基吡啶 ≥99%

Sigma-Aldrich

275875

4-氨基吡啶

蔗糖 ACS reagent

Sigma-Aldrich

S5016

蔗糖

Amar Sahay et al.
Nature, 472(7344), 466-470 (2011-04-05)
Adult hippocampal neurogenesis is a unique form of neural circuit plasticity that results in the generation of new neurons in the dentate gyrus throughout life. Neurons that arise in adults (adult-born neurons) show heightened synaptic plasticity during their maturation and
Estefanía Estévez-Priego et al.
Network neuroscience (Cambridge, Mass.), 4(4), 1160-1180 (2021-01-08)
An elusive phenomenon in network neuroscience is the extent of neuronal activity remodeling upon damage. Here, we investigate the action of gradual synaptic blockade on the effective connectivity in cortical networks in vitro. We use two neuronal cultures configurations-one formed
S I Itazawa et al.
Journal of neurophysiology, 78(5), 2592-2601 (1997-11-14)
Inwardly rectifying and Ca2+-permeable AMPA-type glutamate receptor channels in rat neocortical neurons. J. Neurophysiol. 78: 2592-2605, 1997. Current-voltage (I-V) relations and Ca2+ permeability of alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA)type glutamate receptor channels were investigated in neurons of rat neocortex by using the
Alfredo Gonzalez-Sulser et al.
Neuropharmacology, 60(7-8), 1142-1153 (2010-10-20)
Epileptiform discharges recorded in the 4-aminopyridine (4-AP) in vitro epilepsy model are mediated by glutamatergic and GABAergic signaling. Using a 60-channel perforated multi-electrode array (pMEA) on corticohippocampal slices from 2 to 3 week old mice we recorded interictal- and ictal-like
Qing Hui Chen et al.
American journal of physiology. Regulatory, integrative and comparative physiology, 285(5), R1231-R1239 (2003-07-26)
Blockade of GABA-A receptors in the hypothalamic paraventricular nucleus (PVN) has been repeatedly shown to increase arterial blood pressure (ABP), heart rate (HR), and sympathetic nerve activity (SNA), but the mechanism(s) that underlies this response has not been determined. Here
查看所有相关文献

商品

GABAA Receptors

We offer many products related to GABAA receptors for your research needs.

GABAA Receptors

We offer many products related to GABAA receptors for your research needs.

Potassium Channels

Sigma-Aldrich offers many products related to potassium channels for your research needs.

钾通道

我们可提供多种与钙通道相关的产品以满足您的各类研究需求。

我们的科学家团队拥有各种研究领域经验，包括生命科学、材料科学、化学合成、色谱、分析及许多其他领域.

联系技术服务部门