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About This Item
经验公式（希尔记法）:
C10H12Li3N5O9P2S
CAS号:
分子量:
461.07
MDL號碼:
分類程式碼代碼:
41106305
eCl@ss:
32160414
PubChem物質ID:
NACRES:
NA.77
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![腺苷5′-[γ-硫代]三磷酸盐 四锂盐 ≥75% (HPLC), powder](/deepweb/assets/sigmaaldrich/product/structures/319/398/e29221c2-3649-455b-bd33-583bb017ec7d/640/e29221c2-3649-455b-bd33-583bb017ec7d.png)
化驗
≥80% (HPLC)
形狀
powder
儲存溫度
−20°C
SMILES 字串
[Li+].[Li+].[Li+].Nc1ncnc2n(cnc12)[C@@H]3O[C@H](COP([O-])(=O)OP([O-])([O-])=S)[C@@H](O)[C@H]3O
InChI
1S/C10H15N5O9P2S.3Li/c11-8-5-9(13-2-12-8)15(3-14-5)10-7(17)6(16)4(23-10)1-22-25(18,19)24-26(20,21)27;;;/h2-4,6-7,10,16-17H,1H2,(H,18,19)(H2,11,12,13)(H2,20,21,27);;;/q;3*+1/p-3/t4-,6-,7-,10-;;;/m1.../s1
InChI 密鑰
CPKFUAYUUSSFFZ-MSQVLRTGSA-K
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相关类别
應用
5′-[β-硫代]二磷酸腺苷是AMP依赖性酶系统的底物和抑制剂。 5′-[β-硫代]二磷酸腺苷已被用于探索人食管运动的肌间控制机制以及硝化和非硝化神经递质的效应。
用5′-[β-硫代]二磷酸腺苷三锂盐诱发大鼠神经性疼痛，研究了背角大麻素CB2受体激活对P2Y12和P2Y13（嘌呤受体）受体表达的效应。
生化／生理作用
P2Y 受体激动剂。
特點和優勢
该化合物的相关信息整理于受体分类和信号转导手册的 P2受体：P2Y G蛋白家族 页面。想要浏览手册的其他页面， 请单击此处。
其他說明
不可水解ADP类似物
基底
AMP依赖性酶系统的底物和抑制剂。
訊號詞
Warning
危險聲明
危險分類
Acute Tox. 4 Oral - STOT SE 2
標靶器官
Eyes,Central nervous system
儲存類別代碼
11 - Combustible Solids
水污染物質分類（WGK）
WGK 3
閃點（°F）
Not applicable
閃點（°C）
Not applicable
個人防護裝備
dust mask type N95 (US), Eyeshields, Faceshields, Gloves
其他客户在看
Activation of dorsal horn cannabinoid CB2 receptor suppresses the expression of P2Y 12 and P2Y 13 receptors in neuropathic pain rats
Niu J, et al.
Journal of Neuroinflammation, 14(1), 185-185 (2017)
Tibor Kiss
The European journal of neuroscience, 21(8), 2177-2185 (2005-05-05)
Members of the mytilus inhibitory peptide (MIP) family play an important role in the modulation of many physiological processes in molluscs. The signal transduction pathways affected by the MIP effect have not, however, been elucidated. Application of guanosine 5'-[gamma-thio]triphosphate tetralithium
Alexander K Filippov et al.
The Journal of neuroscience : the official journal of the Society for Neuroscience, 26(36), 9340-9348 (2006-09-08)
We have shown previously that stimulation of heterologously expressed P2Y1 nucleotide receptors inhibits M-type K+ currents in sympathetic neurons. We now report that activation of endogenous P2Y1 receptors induces inhibition of the M-current in rat CA1/CA3 hippocampal pyramidal cells in
B Lecea et al.
American journal of physiology. Gastrointestinal and liver physiology, 300(5), G782-G794 (2011-02-19)
The aim of this study was to explore the myenteric mechanisms of control of human esophageal motility and the effect of nitrergic and nonnitrergic neurotransmitters. Human circular esophageal strips were studied in organ baths and with microelectrodes. Responses following electrical
R Rodríguez-Rodríguez et al.
British journal of pharmacology, 158(6), 1609-1620 (2009-10-23)
Extracellular nucleotides play a crucial role in the regulation of vascular tone and blood flow. Stimulation of endothelial cell P2Y1 receptors evokes concentration-dependent full dilatation of resistance arteries. However, this GPCR can desensitize upon prolonged exposure to the agonist. Our
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