所有图片(2)
About This Item
经验公式（希尔记法）:
C8H13NO2
CAS号:
分子量:
155.19
MDL號碼:
分類程式碼代碼:
12352106
PubChem物質ID:
NACRES:
NA.26
推荐产品
product name
2-氨基-2-去甲冰片羧酸, amino acid transport inhibitor
形狀
powder
技術
ligand binding assay: suitable
顏色
white to off-white
mp
>300 °C (lit.)
SMILES 字串
NC1(C[C@@H]2CC[C@H]1C2)C(O)=O
InChI
1S/C8H13NO2/c9-8(7(10)11)4-5-1-2-6(8)3-5/h5-6H,1-4,9H2,(H,10,11)/t5-,6+,8?/m1/s1
InChI 密鑰
MPUVBVXDFRDIPT-RSHNMJPRSA-N
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相关类别
一般說明
2-氨基-2-去甲冰片羧酸是一种强效大氨基酸转运体抑制剂。它可抑制肿瘤进展和细胞凋亡。
應用
- Thyroid Hormone Transporters in a Human Placental Cell Model.: This study investigates the role of 2-Amino-2-norbornanecarboxylic acid in the transport of thyroid hormones in placental cells, offering insights that could improve understanding of fetal development and maternal health (Chen et al., 2022).
- Metabolic adaptations to hypoxia in the neonatal mouse forebrain can occur independently of the transporters SLC7A5 and SLC3A2.: Research explores how 2-Amino-2-norbornanecarboxylic acid affects metabolic responses to hypoxia in neonatal brain development, providing a foundation for future studies on brain health and neurodevelopment (Fitzgerald et al., 2021).
- Hemocompatible LAT1-inhibitor can induce apoptosis in cancer cells without affecting brain amino acid homeostasis.: This article assesses the potential of 2-Amino-2-norbornanecarboxylic acid as a selective inhibitor that could lead to new treatments for cancer while preserving critical brain functions (Markowicz-Piasecka et al., 2020).
- Regulation of Melanogenesis by the Amino Acid Transporter SLC7A5.: Research demonstrates the utility of 2-Amino-2-norbornanecarboxylic acid in regulating skin pigmentation processes, which could have implications for disorders related to pigmentation (Gaudel et al., 2020).
- Structure of the human LAT1-4F2hc heteromeric amino acid transporter complex.: This study utilizes 2-Amino-2-norbornanecarboxylic acid to elucidate the structure of a key amino acid transporter, which is crucial for understanding nutrient uptake and its implications in various diseases (Yan et al., 2019).
生化／生理作用
2-氨基-2-去甲硼酸 (BCH) 是一种非 Na (+) 依赖性系统特异性底物，与其他系统特异性底物（如该系统特异性底物、 α-（甲氨基）异丁酸和系统 N 特异性底物 L-谷氨酸 γ-异羟肟酸）共同使用，帮助识别、区分和表征细胞中的氨基酸转运系统。
品質
外异构体和内异构体的混合物。
儲存類別代碼
11 - Combustible Solids
水污染物質分類（WGK）
WGK 3
閃點（°F）
Not applicable
閃點（°C）
Not applicable
Discovery of Potent Inhibitors for the Large Neutral Amino Acid Transporter 1 (LAT1) by Structure-Based Methods
Singh N, et al.
International Journal of Molecular Sciences, 20(1), 27-27 (2019)
Hiroyuki Okudaira et al.
Journal of nuclear medicine : official publication, Society of Nuclear Medicine, 52(5), 822-829 (2011-05-04)
Trans-1-amino-3-(18)F-fluorocyclobutanecarboxylic acid (anti-(18)F-FACBC) is an amino acid PET tracer that has shown promise for visualizing prostate cancer. Therefore, we aimed to clarify the anti-(18)F-FACBC transport mechanism in prostate cancer cells. We also studied the fate of anti-(18)F-FACBC after it is
M M Sánchez del Pino et al.
The Journal of biological chemistry, 267(36), 25951-25957 (1992-12-25)
Endothelial cell membranes, the site of the blood-brain barrier, were obtained from the capillaries of cow brain. The luminal and abluminal membranes were separated by centrifugation on a discontinuous Ficoll gradient. Electron microscopy revealed that the membrane preparations consisted almost
Chem. Abstr., 117, 64436p-64436p (1992)
Hisao Imai et al.
Anticancer research, 30(12), 4819-4828 (2010-12-29)
L-type amino acid transporter 1 (LAT1) is highly expressed in various human neoplasms. Antitumor activity of inhibiting LAT1 was analyzed in non-small cell lung cancer (NSCLC). Expression of LAT1 mRNA in 54 lung cancer cell lines was examined by RT-PCR.
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