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Merck
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文件

A3401

Sigma-Aldrich

Ala-Ala-Phe-7-氨基-4-甲基香豆素

protease substrate

别名:

H-Ala-Ala-Phe-AMC

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About This Item

经验公式（希尔记法）:
C25H28N4O5
CAS号:
62037-41-6
分子量:
464.51
MDL號碼:
MFCD00070149
分類程式碼代碼:
12352204
PubChem物質ID:
24890766
NACRES:
NA.32

品質等級

200

化驗

≥98% (TLC)

形狀

powder

溶解度

ethanol: 20 mg/mL, clear, colorless to light yellow

儲存溫度

2-8°C

SMILES 字串

CC(N)C(=O)NC(C)C(=O)NC(Cc1ccccc1)C(=O)Nc2ccc3C(C)=CC(=O)Oc3c2

InChI

1S/C25H28N4O5/c1-14-11-22(30)34-21-13-18(9-10-19(14)21)28-25(33)20(12-17-7-5-4-6-8-17)29-24(32)16(3)27-23(31)15(2)26/h4-11,13,15-16,20H,12,26H2,1-3H3,(H,27,31)(H,28,33)(H,29,32)

InChI 密鑰

FVRLYIFIDKXFHU-UHFFFAOYSA-N

一般說明

丙氨酸-丙氨酸-苯丙氨酸-7-酰胺基-4-甲基香豆素是蛋白水解活性的荧光底物。是带正电荷的底物分子。

應用

丙氨酸-丙氨酸-苯丙氨酸-7-酰胺基-4-甲基香豆素已被用于：
  • 酶促反应混合液的制备
  • 启动三肽基肽酶-1 (TPP1) 酶活性测定中的酶反应
  • 启动溶酶体水解酶活性测定中的测定反应

基底

糜蛋白酶和三肽基肽酶 ii 的底物。

儲存類別代碼

11 - Combustible Solids

水污染物質分類（WGK）

WGK 3

閃點（°F）

Not applicable

閃點（°C）

Not applicable

個人防護裝備

Eyeshields, Gloves, type N95 (US)

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Accumulation of polyubiquitylated proteins in response to Ala-Ala-Phe-chloromethylketone is independent of the inhibition of tripeptidyl peptidase II
Villasevil E M, et al.
Biochimica et Biophysica Acta - Molecular Cell Research, 1803(9), 1094-1105 (2010)
Raffaella Di Giacopo et al.
Journal of the neurological sciences, 356(1-2), 65-71 (2015-07-06)
This work investigated the molecular cause responsible for a late-onset parkinsonism-dystonia phenotype in three Italian siblings, and clinically characterize this condition. Extensive neurophysiological and neuroradiological exams were performed on the three sibs. Most frequent late-onset metabolic diseases were ruled out
R M Bålöw et al.
The Journal of biological chemistry, 261(5), 2409-2417 (1986-02-15)
An extralysosomal tripeptide-releasing aminopeptidase was recently discovered in rat liver (Bålöw, R.-M., Ragnarsson, U., and Zetterqvist, O. (1983) J. Biol. Chem. 258, 11622-11628). In the present work this tripeptidyl peptidase is shown to occur in several rat tissues and in
Effect of interfacial properties on the activation volume of adsorbed enzymes
Schuabb V, et al.
Colloids and Surfaces. B, Biointerfaces, 140, 497-504 (2016)
NADPH oxidase promotes Parkinsonian phenotypes by impairing autophagic flux in an mTORC1-independent fashion in a cellular model of Parkinson?s disease
Pal R, et al.
Scientific reports, 6, 22866-22866 (2016)
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