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應用
异补骨脂素是一种有角的呋喃香豆素,可用作可光活化的分子,与 DNA 和不饱和脂肪酸反应形成单加合物。异补骨脂素可作为潜在的光疗法进行研究,并了解其作用机制和对 RNA 和 DNA 合成的影响。
生化/生理作用
角呋喃香豆素具有多种光生物效应。在长波紫外线照射下,与双链 DNA 形成单加合物,并与不饱和脂肪酸反应。抑制 Ehrlich 腹水肿瘤细胞中的 DNA 和 RNA 合成,以及细胞复制。
訊號詞
Warning
危險分類
Acute Tox. 4 Oral - Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
標靶器官
Respiratory system
儲存類別代碼
11 - Combustible Solids
水污染物質分類(WGK)
WGK 3
閃點(°F)
Not applicable
閃點(°C)
Not applicable
個人防護裝備
Eyeshields, Faceshields, Gloves, type P3 (EN 143) respirator cartridges
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Annals of the New York Academy of Sciences, 1171, 334-344 (2009-09-03)
In this review we summarize the structure and biological effects of linear and angular psoralens. These compounds exhibit interesting biological effects on the cell cycle, apoptosis and differentiation. These molecules should be considered promising drugs in the therapy of several
Journal of medicinal chemistry, 53(4), 1519-1533 (2010-01-23)
By using a cell-based high throughput screening campaign, a novel angelicin derivative 6a was identified to inhibit influenza A (H1N1) virus induced cytopathic effect in Madin-Darby canine kidney cell culture in low micromolar range. Detailed structure-activity relationship studies of 6a
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Angelicin is a furocoumarin found in Psoralea corylifolia L. fruit. The purpose of this study was to investigate the protective ability of angelicin against inflammation in lipopolysaccharide (LPS)-stimulated RAW 264.7 cells and LPS-induced in vivo acute lung injury model. The
Analytica chimica acta, 650(2), 160-166 (2009-09-02)
A method using high performance liquid chromatography with photodiode-array detection (HPLC-DAD) coupled with alternating trilinear decomposition (ATLD) algorithm was proposed for simultaneous determination of psoralen and isopsoralen in plasma and Chinese medicine "Xian Ling Gu Bao" capsule (XLGBC). In this
Organic letters, 14(8), 2114-2117 (2012-04-07)
The oxidative dearomatization of 3-(3-alkynyl-4-hydroxyphenyl)propanoic acid is combined with a cascade transition-metal catalyzed cyclization/addition/aromatization/lactamization sequence, which provides a novel approach to prepare furoquinolinone and angelicin derivatives in a convergent and efficient manner.
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DNA damage and repair mechanism is vital for maintaining DNA integrity. Damage to cellular DNA is involved in mutagenesis, the development of cancer among others.
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