推荐产品
品質等級
化驗
≥98% (HPLC)
形狀
powder
顏色
white to beige
溶解度
DMSO: 5 mg/mL, clear (warmed)
儲存溫度
−20°C
SMILES 字串
CC(C)=CCC1=C(C=C(OC2=O)C(C(OC3=C4)=C2C3=CC=C4O)=C1)O
InChI
1S/C20H16O5/c1-10(2)3-4-11-7-14-17(9-15(11)22)25-20(23)18-13-6-5-12(21)8-16(13)24-19(14)18/h3,5-9,21-22H,4H2,1-2H3
InChI 密鑰
YABIJLLNNFURIJ-UHFFFAOYSA-N
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生化／生理作用
补骨脂定是一种从补骨脂中提取的 Coumestan 衍生物。它能通过抑制环氧酶-2（COX-2）和5-脂氧合酶（5-LOX）表达表现出抗炎特性。除了抗癌和抗炎效果之外，补骨脂定还具有抗氧化、抗菌和抗抑郁作用。补骨脂定参与胰岛素信号的调控。它是用于治疗出血、遗尿、尿频、白癜风和牛皮癣等传统药物的主要成分。
补骨脂素是一种呋喃香豆素的天然产物，其已用于中药。 补骨脂素是一种PTP1B抑制剂，已被证明具有多种抗癌活性。补骨脂素在不依赖雄激素的前列腺癌细胞中可诱导ROS生成，从而导致细胞增殖受到抑制。研究已经发现补骨脂素可下调NOTCH1信号转导，并导致乳腺癌干细胞和乳腺癌细胞中的生长停滞。
特點和優勢
该化合物是细胞凋亡研究的推荐产品。点击此处，了解更多精选的细胞凋亡产品。了解更多有关用于其他研究领域的生物活性小分子的信息，请访问sigma.com/discover-bsm。
訊號詞
Warning
危險聲明
危險分類
Acute Tox. 4 Oral
儲存類別代碼
11 - Combustible Solids
水污染物質分類（WGK）
WGK 3
閃點（°F）
Not applicable
閃點（°C）
Not applicable
Luhua Zhao et al.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, 821(1), 67-74 (2005-05-21)
High-performance liquid chromatography (HPLC) was developed for fingerprint analysis of Psoralea corylifolia. Liquid chromatography-electrospray ionization-tandem mass spectrometry (LC-ESI-MSn) technique was first employed to identify the components of the fingerprint. The samples were separated with an Alltima C18 column (250 mm
Raj Kumar et al.
Molecular cancer therapeutics, 9(9), 2488-2496 (2010-08-26)
Epidermal growth factor receptor (EGFR) activation is an important event that regulates mitogenic signaling, such as the Raf, mitogen-activated protein kinase (MAPK), and extracellular signal-regulated kinase 1/2 cascades. EGFR activation has been implicated in the transition of prostate cancer from
Y M Yang et al.
Planta medica, 62(4), 353-354 (1996-08-01)
A cytotoxic coumestan derivative, psoralidin (1), was isolated from the seed of Psoralea corylifolia. The IC50 values of 1 against SNU-1 and SNU-16 carcinoma cell lines were 53 and 203 micrograms/ml, respectively, indicating cytotoxic activity against stomach carcinoma cell lines.
Sung-Jin Lee et al.
Archives of pharmacal research, 32(7), 1061-1065 (2009-07-31)
Quinone reductase (QR) is a protective phase II enzyme against mutagens and carcinogens which is inducible by a number of chemical compounds in plants. This study was carried out to investigate effects of the fractions from the seeds of Psoralea
W Mar et al.
Archives of pharmacal research, 24(3), 211-213 (2001-07-07)
A coumestan derivative, psoralidin (1) was found to be a cytotoxic principle of the seeds of Psoralea corylifolia L. (Leguminosae) with the IC50 values of 0.3 and 0.4 microg/ml against the HT-29 (colon) and MCF-7 (breast) human cancer cell lines
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