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應用
来自兔的促凝血酶原激酶已用于:
- 作为组织因子促凝活性测定（TF-PCA）的标准品
- 肺栓塞试验
- 作为人血浆凝血试验中的阳性对照
生化／生理作用
凝血活酶（组织因子）是一种跨膜蛋白，是血液凝固的主要体内激活剂，可导致凝血酶的生成和纤维蛋白的沉积。它在凝血蛋白酶级联的激活中也很重要，并参与了脓毒症的致死性。
来自兔的促凝血酶原激酶可用于在动物模型中产生弥散性血管内凝血（DIC）。
包裝
一个含3-4 mg凝血活酶的小瓶。
重構
将小瓶中的内容物重溶于4 ml 10 mm CaCl2中
訊號詞
Danger
危險聲明
危險分類
Resp. Sens. 1
儲存類別代碼
11 - Combustible Solids
水污染物質分類（WGK）
WGK 1
個人防護裝備
Eyeshields, Gloves, type N95 (US)
其他客户在看
M E Bromberg et al.
Proceedings of the National Academy of Sciences of the United States of America, 92(18), 8205-8209 (1995-08-29)
Several studies have established a link between blood coagulation and cancer, and more specifically between tissue factor (TF), a transmembrane protein involved in initiating blood coagulation, and tumor metastasis. In the study reported here, a murine model of human melanoma
J Erlich et al.
Infection and immunity, 67(5), 2540-2546 (1999-05-04)
Tissue factor (TF) is the major activator of the coagulation protease cascade and contributes to lethality in sepsis. Despite several studies analyzing TF expression in animal models of endotoxemia, there remains debate about the cell types that are induced to
Nan Zhang et al.
The Journal of experimental medicine, 216(6), 1291-1300 (2019-05-03)
Macrophages resident in different organs express distinct genes, but understanding how this diversity fits into tissue-specific features is limited. Here, we show that selective expression of coagulation factor V (FV) by resident peritoneal macrophages in mice promotes bacterial clearance in
Richard Beatson et al.
Communications biology, 3(1), 644-644 (2020-11-06)
The tumour microenvironment plays a crucial role in the growth and progression of cancer, and the presence of tumour-associated macrophages (TAMs) is associated with poor prognosis. Recent studies have demonstrated that TAMs display transcriptomic, phenotypic, functional and geographical diversity. Here
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