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Merck
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主要文件

10820

Sigma-Aldrich

抑肽酶 来源于牛肺

lyophilized, ~80% (HPCE), crystalline (fine), white, ≥3500 U/mg

别名:

BPTI, 抑肽酶, 牛胰胰蛋白酶抑制剂, 胰蛋白酶抑制剂（碱性）

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About This Item

经验公式（希尔记法）:
C284H432N84O79S7
CAS号:
9087-70-1
分子量:
6511.44
EC號碼:
232-994-9
MDL號碼:
MFCD00130541
分類程式碼代碼:
12352202
NACRES:
NA.26

生物源

bovine lung

化驗

~80% (HPCE)

形狀

crystalline (fine)

品質

lyophilized

比活性

≥3500 U/mg

分子量

~6,500

技術

electrophoresis: suitable

顏色

white

溶解度

phosphate buffer: 5 mg/mL, clear, colorless (PH 7.6 (70 mm phosphate))

UniProt登錄號

P00974

儲存溫度

2-8°C

SMILES 字串

S1SCC2NC(=O)CNC(=O)CNC(=O)C(NC(=O)C(NC(=O)C(NC(=O)C(NC(=O)C(NC(=O)C5NC(=O)C(NC(=O)CNC(=O)C(NC(=O)C(NC(=O)C(NC(=O)C(NC(=O)C(NC(=O)C(NC(=O)C(NC(=O)C(NC(=O)C(NC(=O)C(NC(=O)C(NC(=O)C(NC(=O)C(NC(=O)C(NC(=O)C9N(CCC9)C(=O)CNC(=O)C(NC(=O)C(NC(=O)C%11N(CCC%11)C(=O

InChI

1S/C284H432N84O79S7/c1-21-144(9)222-271(439)337-174(68-46-105-309-282(300)301)239(407)340-187(120-160-77-85-164(374)86-78-160)251(419)341-185(116-156-55-29-24-30-56-156)250(418)342-188(121-161-79-87-165(375)88-80-161)252(420)346-191(123-208(291)378)246(41

InChI 密鑰

ZPNFWUPYTFPOJU-UHFFFAOYSA-N

基因資訊

cow ... PTI(404172)

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應用

抑肽酶被大量用作胰蛋白酶抑制剂。

生化／生理作用

抑肽酶是一种竞争性丝氨酸蛋白酶抑制剂，可与酶的活性位点组成稳定的复合酶并同时对其进行封闭。 这种结合是可逆的，而且绝大多数抑肽酶-蛋白酶复合物可在极端的pH >10 or < 3水平时发生解离。 从结构上来说，抑肽酶是一种来自牛肺的单体球状蛋白，由58个氨基酸组成并排列在具有三个交联二硫键的单个多肽链中。

單位定義

一个胰蛋白酶抑制剂单位（TIU）可将两个胰蛋白酶单位的活性降低50％，而其中一个胰蛋白酶单位在pH 7.8和25℃下可每分钟水解1.0 μ摩尔的N-α-苯甲酰基-DL-精氨酸对硝基苯胺。另一种常用的单位是KIU，而1 TIU = 1,300 KIU。
1 U corresponds to 1 biological kallikrein inhibitor unit (KIU)

儲存類別代碼

11 - Combustible Solids

水污染物質分類（WGK）

WGK 1

閃點（°F）

Not applicable

閃點（°C）

Not applicable

個人防護裝備

Eyeshields, Gloves, type N95 (US)

历史批次信息供参考:

分析证书(COA)

Lot/Batch Number
BCCG9260
BCCG9261
BCCF5347
BCCF5348
BCCC7867

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