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Merck

Y0001637

左卡巴斯汀

European Pharmacopoeia (EP) Reference Standard

别名:

左卡巴斯汀 盐酸盐, R50547, [3S-[1(顺式),3α,4β]]-1-[4-氰基-4-(4-氟苯基)环己基]-3-甲基-4-苯基-4-哌啶羧酸, 左旋多巴, 立复汀

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About This Item

经验公式(希尔记法):
C26H29N2O2F·HCl
CAS号:
分子量:
456.98
MDL號碼:
分類程式碼代碼:
41116107
PubChem物質ID:
NACRES:
NA.24

等級

pharmaceutical primary standard

API 家族

levocabastine

製造商/商標名

EDQM

應用

pharmaceutical (small molecule)

格式

neat

儲存溫度

2-8°C

SMILES 字串

Cl[H].C[C@@H]1CN(CC[C@]1(C(O)=O)c2ccccc2)[C@@H]3CC[C@@](CC3)(C#N)c4ccc(F)cc4

InChI

1S/C26H29FN2O2.ClH/c1-19-17-29(16-15-26(19,24(30)31)21-5-3-2-4-6-21)23-11-13-25(18-28,14-12-23)20-7-9-22(27)10-8-20;/h2-10,19,23H,11-17H2,1H3,(H,30,31);1H/t19-,23-,25-,26-;/m1./s1

InChI 密鑰

OICFWWJHIMKBCD-VALQNVSPSA-N

基因資訊

human ... HRH1(3269)

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一般說明

This product is provided as delivered and specified by the issuing Pharmacopoeia. All information provided in support of this product, including SDS and any product information leaflets have been developed and issued under the Authority of the issuing Pharmacopoeia.For further information and support please go to the website of the issuing Pharmacopoeia.

應用

Levocabastine for system suitability 2 EP Reference standard, intended for use in laboratory tests only as specifically prescribed in the European Pharmacopoeia.

生化/生理作用

非肽类组胺H1 受体拮抗剂;神经降压素NTS2受体配体。

包裝

The product is delivered as supplied by the issuing Pharmacopoeia. For the current unit quantity, please visit the EDQM reference substance catalogue.

其他說明

Sales restrictions may apply.

象形圖

Exclamation mark

訊號詞

Warning

危險聲明

危險分類

Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3

標靶器官

Respiratory system

儲存類別代碼

11 - Combustible Solids

水污染物質分類(WGK)

WGK 3


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Megumi Akiyoshi et al.
Nihon yakurigaku zasshi. Folia pharmacologica Japonica, 119(3), 175-184 (2002-03-28)
Levocabastine is a selective histamine H1-receptor antagonist exerting inhibitory effects on the release of chemical mediators from mast cells and on the chemotaxis of polymorphonuclear leukocytes and eosinophils. Both histamine and antigens induced conjunctivitis was inhibited by levocabastine in several
Jian Jiao et al.
ORL; journal for oto-rhino-laryngology and its related specialties, 76(3), 127-136 (2014-06-28)
The aim of this study was to investigate the effect of the corticosteroids, the antihistamines, and the preservatives benzalkonium chloride (BKC) and potassium sorbate (PS) in intranasal medications on human nasal epithelial ciliary beat frequency (CBF). Primary ciliated epithelial cell

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