Y0001599

蟛蜞菊内酯

European Pharmacopoeia (EP) Reference Standard

• 别名: 1,8,9-三羟基-3-甲氧基-6 H -苯并呋喃 [3,2- c ] ] 苯并吡喃-6-酮, 5-甲氧基-5,11,12-三羟基香豆素
• 经验公式（希尔记法）: C₁₆H₁₀O₇
• CAS号: 524-12-9
• 分子量: 314.25
• MDL號碼: MFCD07778564
• 分類程式碼代碼: 41116107
• PubChem物質ID: 329831504
• NACRES: NA.24

属性

• 等級: pharmaceutical primary standard
• API 家族: wedelolactone
• 製造商／商標名: EDQM
• 應用: pharmaceutical (small molecule)
• 格式: neat
• 儲存溫度: −20°C
• SMILES 字串: COc1cc(O)c-2c(OC(=O)c3c-2oc4cc(O)c(O)cc34)c1
• InChI: 1S/C16H10O7/c1-21-6-2-10(19)14-12(3-6)23-16(20)13-7-4-8(17)9(18)5-11(7)22-15(13)14/h2-5,17-19H,1H3
• InChI 密鑰: XQDCKJKKMFWXGB-UHFFFAOYSA-N

说明

一般說明

This product is provided as delivered and specified by the issuing Pharmacopoeia. All information provided in support of this product, including SDS and any product information leaflets have been developed and issued under the Authority of the issuing Pharmacopoeia.For further information and support please go to the website of the issuing Pharmacopoeia.

應用

Wedelolactone EP Reference standard, intended for use in laboratory tests only as specifically prescribed in the European Pharmacopoeia.

生化／生理作用

蟛蜞菊内酯通过阻断 IκBα 的磷酸化和降解抑制细胞内的 NF-κB- 介导的基因转录。IKKα 和 β激酶活性不可逆抑制剂（IC ₅₀ <10βM）。蟛蜞菊内酯对 p38 MAP 激酶或 Akt 没有影响。

包裝

The product is delivered as supplied by the issuing Pharmacopoeia. For the current unit quantity, please visit the EDQM reference substance catalogue.

其他說明

Sales restrictions may apply.

安全信息

• 象形圖: GHS07
• 訊號詞: Warning
• 危險聲明: H302
• 防範說明: P264 - P270 - P301 + P312 - P501
• 危險分類: Acute Tox. 4 Oral
• 儲存類別代碼: 11 - Combustible Solids
• 水污染物質分類（WGK）: WGK 1