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Merck

PHR1720

Supelco

氯米帕明

Pharmaceutical Secondary Standard; Certified Reference Material

别名:

氯米帕明 盐酸盐

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About This Item

经验公式(希尔记法):
C19H23ClN2 · HCl
CAS号:
分子量:
351.31
EC號碼:
MDL號碼:
分類程式碼代碼:
41116107
PubChem物質ID:
NACRES:
NA.24

等級

certified reference material
pharmaceutical secondary standard

品質等級

agency

traceable to BP
traceable to Ph. Eur. C2360000
traceable to USP 1140427

API 家族

clomipramine

CofA

current certificate can be downloaded

包裝

pkg of 1 g

技術

HPLC: suitable
gas chromatography (GC): suitable

應用

pharmaceutical (small molecule)

格式

neat

儲存溫度

2-30°C

SMILES 字串

Cl.CN(C)CCCN1c2ccccc2CCc3ccc(Cl)cc13

InChI

1S/C19H23ClN2.ClH/c1-21(2)12-5-13-22-18-7-4-3-6-15(18)8-9-16-10-11-17(20)14-19(16)22;/h3-4,6-7,10-11,14H,5,8-9,12-13H2,1-2H3;1H

InChI 密鑰

WIMWMKZEIBHDTH-UHFFFAOYSA-N

基因資訊

human ... SLC6A4(6532)

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一般說明

Pharmaceutical secondary standards for application in quality control, provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards.
Clomipramine hydrochloride is one of the dibenzazepine tricyclic antidepressants that inhibits noradrenalin and serotonin reuptake in central nervous system. It also shows antimuscarinic properties.

應用

Clomipramine hydrochloride may be used as a pharmaceutical reference standard for the determination of the analyte in traditional Chinese medicine and pharmaceutical formulations by analytical and cyclodextrin-modified capillary zone electrophoresis techniques.
These Secondary Standards are qualified as Certified Reference Materials. These are suitable for use in several analytical applications including but not limited to pharma release testing, pharma method development for qualitative and quantitative analyses, food and beverage quality control testing, and other calibration requirements.

分析報告

These secondary standards offer multi-traceability to the USP, EP and BP primary standards, where they are available.

其他說明

This Certified Reference Material (CRM) is produced and certified in accordance with ISO 17034 and ISO/IEC 17025. All information regarding the use of this CRM can be found on the certificate of analysis.

腳註

To see an example of a Certificate of Analysis for this material enter LRAC3902 in the Documents slot below. This is an example certificate only and may not be the lot that you receive.

訊號詞

Danger

危險分類

Acute Tox. 4 Oral - Aquatic Acute 1 - Aquatic Chronic 1 - STOT SE 1 - STOT SE 3

標靶器官

Central nervous system, Central nervous system,Cardiovascular

儲存類別代碼

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

水污染物質分類(WGK)

WGK 3

閃點(°F)

Not applicable

閃點(°C)

Not applicable


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分析证书(COA)

Lot/Batch Number

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访问文档库

Multicommutated flow system for the chemiluminometric determination of clomipramine in pharmaceutical preparations.
Marques KL, et al.
Analytica Chimica Acta, 518(1-2), 31-36 (2004)
Method for simultaneous determination of eight cyclic antidepressants by cyclodextrin-modified capillary zone electrophoresis: applications in pharmaceuticals.
Kou HS, et al.
Analytica Chimica Acta, 525(1), 23-30 (2004)
HPLC and GC?MS screening of Chinese proprietary medicine for undeclared therapeutic substances.
Liu SY, et al.
Journal of Pharmaceutical and Biomedical Analysis, 24(5-6), 983-992 (2001)

商品

-isomer basis, ≥98% (GC), 15% Z-isomer basis, powder; Norclomipramine hydrochloride, ~99% (TLC), powder; Imipramine hydrochloride solution, drug standard, 1.0 mg/mL in methanol; Amitriptyline hydrochloride, ≥98% (TLC), powder; Clomipramine hydrochloride, ≥98% (HPLC), powder

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