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Merck

PHR1580

Supelco

十二烷酸

Pharmaceutical Secondary Standard; Certified Reference Material

别名:

十二烷酸, NSC 5026

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About This Item

线性分子式:
CH3(CH2)10COOH
CAS号:
分子量:
200.32
Beilstein:
1099477
EC號碼:
MDL號碼:
分類程式碼代碼:
41116107
PubChem物質ID:
NACRES:
NA.24

等級

certified reference material
pharmaceutical secondary standard

品質等級

agency

traceable to Ph. Eur. Y0001474
traceable to USP 1356949

API 家族

lauric acid

CofA

current certificate can be downloaded

包裝

pkg of 1 g

技術

HPLC: suitable
gas chromatography (GC): suitable

應用

pharmaceutical (small molecule)

格式

neat

儲存溫度

2-30°C

SMILES 字串

CCCCCCCCCCCC(O)=O

InChI

1S/C12H24O2/c1-2-3-4-5-6-7-8-9-10-11-12(13)14/h2-11H2,1H3,(H,13,14)

InChI 密鑰

POULHZVOKOAJMA-UHFFFAOYSA-N

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一般說明

Lauric acid finds wide applications in cosmetics and food products. It has been tested for its use as an enhancer for topical penetration and transdermal absorption. It is used as a stabilizer for oil-in-emulsions.
Pharmaceutical secondary standards for application in quality control, provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards.

應用

Lauric acid may be used as a pharmaceutical reference standard for the determination of the analyte in biopharmaceutical formulations by chromatography techniques.
These Secondary Standards are qualified as Certified Reference Materials. These are suitable for use in several analytical applications including but not limited to pharma release testing, pharma method development for qualitative and quantitative analyses, food and beverage quality control testing, and other calibration requirements.

生化/生理作用

CYP 4A11底物

分析報告

These secondary standards offer multi-traceability to the USP, EP and BP primary standards, where they are available.

其他說明

This Certified Reference Material (CRM) is produced and certified in accordance with ISO 17034 and ISO/IEC 17025. All information regarding the use of this CRM can be found on the certificate of analysis.

腳註

To see an example of a Certificate of Analysis for this material enter LRAC0576 in the slot below. This is an example certificate only and may not be the lot that you receive.

推薦產品

Find a digital Reference Material for this product available on our online platform ChemisTwin® for NMR. You can use this digital equivalent on ChemisTwin® for your sample identity confirmation and compound quantification (with digital external standard). An NMR spectrum of this substance can be viewed and an online comparison against your sample can be performed with a few mouseclicks. Learn more here and start your free trial.

象形圖

Corrosion

訊號詞

Danger

危險聲明

危險分類

Eye Dam. 1

儲存類別代碼

13 - Non Combustible Solids

水污染物質分類(WGK)

WGK 1

閃點(°F)

348.8 °F - closed cup

閃點(°C)

176 °C - closed cup


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分析证书(COA)

Lot/Batch Number

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访问文档库

Pharmaceutical formulation of HSA hybrid coated iron oxide nanoparticles for magnetic drug targeting
Zaloga J, et al.
European Journal of Pharmaceutics and Biopharmaceutics, 101(11), 152-162 (2016)
Handbook of Pharmaceutical Excipients, 28(5), 1194-1210 (2009)
Polysorbate 20 degradation in biopharmaceutical formulations: quantification of free fatty acids, characterization of particulates, and insights into the degradation mechanism
Tomlinson A, et al.
Molecular Pharmaceutics, 12(11), 3805-3815 (2015)
The degradation of polysorbates 20 and 80 and its potential impact on the stability of biotherapeutics
Kishore RSK, et al.
Pharmaceutical Research, 28(5), 1194-1210 (2011)

实验方案

In this study, SPME was used for the analysis of free fatty acids in Parmesan cheese using a 65 μm Carbowax/divinylbenzene (DVB) SPME fiber. Headspace extraction of the cheese sample was conducted at 65 °C for 15 minutes and analyzed by GC with FID detection. SPME is ideal for analyzing the volatiles associated with solid food samples. The phase chemistry of the Nukol GC column provides excellent peak shape of acidic compounds.

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