N5410

烟酸

meets USP testing specifications

• 别名: 3-吡啶甲酸, 吡啶-3-羧酸, 尼亚生, 抗糙皮病因子, 维生素 B₃
• 经验公式（希尔记法）: C₆H₅NO₂
• CAS号: 59-67-6
• 分子量: 123.11
• Beilstein: 109591
• EC號碼: 200-441-0
• MDL號碼: MFCD00006391
• 分類程式碼代碼: 12352106
• PubChem物質ID: 24897734
• NACRES: NA.21

属性

• 生物源: synthetic (organic)
• 品質等級: 200
• agency: USP/NF; meets USP testing specifications
• 化驗: 99.0-101.0% dry basis
• 形狀: powder
• 顏色: white
• mp: 236-239 °C (lit.)
• 應用: pharmaceutical (small molecule)
• SMILES 字串: OC(=O)c1cccnc1
• InChI: 1S/C6H5NO2/c8-6(9)5-2-1-3-7-4-5/h1-4H,(H,8,9)
• InChI 密鑰: PVNIIMVLHYAWGP-UHFFFAOYSA-N
• 基因資訊: human ... CYP1A2(1544) ; rat ... Chrnb2(54239)

说明

一般說明

Nicotinic acid, also referred to as niacin or as vitamin B₃, is a water-soluble vitamin. Nicotinic acid is synthesized from the amino acid tryptophan and is present majorly in peanuts, fish and lean meat.

應用

Nicotinic acid has been used as an antioxidant to evaluate its protective functionality in colon LoVo cell lines against doxorubicin induced cytotoxicity.

生化／生理作用

Nicotinic modulates lipid metabolism and may be useful in treating dyslipidemia. It is an antioxidant and acts as a coenzyme in the form of nicotinamide adenine nucleotides. Deficiency of niacin leads to enhanced lipid peroxidation and is also implicated in Crohn′s disease Deficiency also impacts DNA repair and also leads to skin and gastrointestinal disorder, pellagra. Nicotinic acid reduces the low-density lipoprotein (LDL) synthesis and improves high-density lipoprotein (HDL) levels.

安全信息

• 象形圖: GHS07
• 訊號詞: Warning
• 危險聲明: H319
• 防範說明: P264 - P280 - P305 + P351 + P338 - P337 + P313
• 危險分類: Eye Irrit. 2
• 儲存類別代碼: 11 - Combustible Solids
• 水污染物質分類（WGK）: WGK 1
• 閃點（°F）: 379.4 °F - closed cup
• 閃點（°C）: 193 °C - closed cup
• 個人防護裝備: dust mask type N95 (US), Eyeshields, Gloves