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H7126

Supelco

羟钴胺 盐酸盐

analytical standard

别名:

维生素 B 12a

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About This Item

经验公式（希尔记法）:
C62H89CoN13O15P · HCl
CAS号:
59461-30-2
分子量:
1382.82
EC號碼:
261-772-4
MDL號碼:
MFCD00167463
分類程式碼代碼:
41116107
PubChem物質ID:
329815239
NACRES:
NA.24

等級

analytical standard

品質等級

100

化驗

≥95%

技術

HPLC: suitable
gas chromatography (GC): suitable

顏色

dark red to brown-red

應用

forensics and toxicology
veterinary
vitamins, nutraceuticals, and natural products

格式

neat

儲存溫度

2-8°C

SMILES 字串

Cl.C[C@H](CNC(=O)CC[C@]1(C)[C@@H](CC(N)=O)[C@H]2N([Co+]O)C1=C(C)C3=NC(=CC4=NC(=C(C)C5=N[C@]2(C)[C@@](C)(CC(N)=O)[C@@H]5CCC(N)=O)[C@@](C)(CC(N)=O)[C@@H]4CCC(N)=O)C(C)(C)[C@@H]3CCC(N)=O)OP([O-])(=O)O[C@H]6[C@@H](O)[C@H](O[C@@H]6CO)n7cnc8cc(C)c(C)cc78

InChI

1S/C62H90N13O14P.ClH.Co.H2O/c1-29-20-39-40(21-30(29)2)75(28-70-39)57-52(84)53(41(27-76)87-57)89-90(85,86)88-31(3)26-69-49(83)18-19-59(8)37(22-46(66)80)56-62(11)61(10,25-48(68)82)36(14-17-45(65)79)51(74-62)33(5)55-60(9,24-47(67)81)34(12-15-43(63)77)38(71-55)23-42-58(6,7)35(13-16-44(64)78)50(72-42)32(4)54(59)73-56;;;/h20-21,23,28,31,34-37,41,52-53,56-57,76,84H,12-19,22,24-27H2,1-11H3,(H15,63,64,65,66,67,68,69,71,72,73,74,77,78,79,80,81,82,83,85,86);1H;;1H2/q;;+3;/p-3/t31-,34-,35-,36-,37+,41-,52-,53-,56-,57+,59-,60+,61+,62+;;;/m1.../s1

InChI 密鑰

KEHNCSYXYMMUCO-BXSGNKEGSA-K

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相关类别

一般說明

维生素B12a是一种有机衍生物，可用作氰化物中毒的有效解毒剂。它是维生素B12的储存和输送形式，其作用方式涉及无毒氰钴胺素的形成。

應用

有关合适仪器技术的更多信息，请参考产品分析证书。如需进一步支持，请联系技术服务部门。
维生素B12a 盐酸盐已用作液相色谱-质谱联用（LC-MS / MS）分析猪血浆样品中羟考拉巴明的分析标准。
维生素B12a可用作分析参考标准品，用于通过微孔反相HPLC结合分光光度法、离子喷雾电离质谱和电感耦合等离子体质谱检测定量测定药物制剂中的分析物。

儲存類別代碼

11 - Combustible Solids

水污染物質分類（WGK）

WGK 3

閃點（°F）

Not applicable

閃點（°C）

Not applicable

個人防護裝備

Eyeshields, Gloves, type N95 (US)

从最新的版本中选择一种：

分析证书(COA)

Lot/Batch Number
MKCL8213
SLBQ3950V
SLBN2058V
SLBL0155V
SLBF0456V

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Determination of cobalamins and cobinamides by microbore reversed-phase HPLC with spectrophotometric, ion-spray ionization MS and inductively coupled plasma MS detection
Chassaigne H and Lobinski R
Analytica Chimica Acta, 359(3), 227-235 (1998)
Simultaneous determination of hydroxocobalamin and its cyanide complex cyanocobalamin in human plasma by high-performance liquid chromatography Application to pharmacokinetic studies after high-dose hydroxocobalamin as an antidote for severe cyanide poisoning
Astier A and Baud JF
Journal of Chromatography. B, Biomedical Sciences and Applications, 667(1), 129-135 (1995)
R Pace et al.
Clinical toxicology (Philadelphia, Pa.), 52(7), 647-650 (2014-08-05)
Pre-hospital administration of hydroxocobalamin (B12a) is used for empiric treatment of cyanide poisoning because cyanide poisoning is difficult to identify and requires immediate treatment. B12a interferes with the accuracy of several blood laboratory tests. This study aimed to explore how
Jasmin Federizon et al.
Pharmaceutics, 13(1) (2021-01-21)
Cobalt porphyrin phospholipid (CoPoP) can incorporate within bilayers to enable non-covalent surface-display of antigens on liposomes by mixing with proteins bearing a polyhistidine tag (his-tag); however, the mechanisms for how this occurs are poorly understood. These were investigated using the
Harvey A Schwertner et al.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, 905, 10-16 (2012-09-04)
Cyanide poisoning occurs in individuals after fire smoke inhalation and after oral ingestion of cyanide. Hydroxocobalamin (HOCbl), a hydroxylated form of vitamin B(12), is often used as an antidote to treat cyanide toxicity. It has a high affinity for cyanide
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