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Merck

V6629

Sigma-Aldrich

维生素 B 12

BioReagent, suitable for cell culture, suitable for insect cell culture, suitable for plant cell culture, ≥98%

别名:

α-(5,6-Dimethylbenzimidazolyl)cyanocobamide, CN-Cbl, Cyanocob(III)alamin, 氰钴胺

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About This Item

经验公式(希尔记法):
C63H88CoN14O14P
CAS号:
分子量:
1355.37
Beilstein:
4122889
EC號碼:
分類程式碼代碼:
12352205
eCl@ss:
34058004
PubChem物質ID:
NACRES:
NA.75

生物源

synthetic ((organic))

品質等級

產品線

BioReagent

化驗

≥98%

形狀

powder

分子量

Mw 1355.37 g/mol

技術

cell culture | insect: suitable
cell culture | mammalian: suitable
cell culture | plant: suitable

顏色

red to brown

pH值

6

溶解度

water: soluble 50 mg/mL, dark red

儲存溫度

2-8°C

SMILES 字串

C/C(C1=N[C@]([C@]([C@H](CC(N)=O)[C@@]/2(C)CCC(NC[C@@H](OP([O-])(O[C@H]3[C@@H](O)[C@@H](N4C=[N]5C6=C4C=C(C)C(C)=C6)O[C@@H]3CO)=O)C)=O)([H])N([Co+]5C#N)C2=C(C)/C([C@@H](CCC(N)=O)C/7(C)C)=NC7=C/8)(C)[C@@](C)(CC(N)=O)[C@@H]1CCC(N)=O)=C9N=C8[C@@H](CCC(N)=O)[C@

InChI

1S/C62H90N13O14P.CN.Co/c1-29-20-39-40(21-30(29)2)75(28-70-39)57-52(84)53(41(27-76)87-57)89-90(85,86)88-31(3)26-69-49(83)18-19-59(8)37(22-46(66)80)56-62(11)61(10,25-48(68)82)36(14-17-45(65)79)51(74-62)33(5)55-60(9,24-47(67)81)34(12-15-43(63)77)38(71-55)23-42-58(6,7)35(13-16-44(64)78)50(72-42)32(4)54(59)73-56;1-2;/h20-21,23,28,31,34-37,41,52-53,56-57,76,84H,12-19,22,24-27H2,1-11H3,(H15,63,64,65,66,67,68,69,71,72,73,74,77,78,79,80,81,82,83,85,86);;/q;;+2/p-2/t31-,34-,35-,36-,37+,41-,52-,53-,56-,57?,59-,60+,61+,62+;;/m1../s1

InChI 密鑰

RMRCNWBMXRMIRW-QJRSUKKJSA-L

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一般說明

氰钴胺(B12)是一种水溶性维生素,通常称为钴胺素。乳制品、肉和蛋是这种维生素的主要来源。

應用

维生素B12已用于:
  • 用作Erdschreiber′s培养基组分
  • 用作杜氏改良Eagle′s培养基的补充剂,用于从新生和成年大鼠中分离出的心室肌细胞
  • 雄性鹌鹑口服用药,用于研究其在减少亚硒酸钠中毒体内负面影响方面的作用。
  • 作为人成肌细胞分化用DMEM培养基/199 (M199)的补充剂。

生化/生理作用

维生素B12代谢为其甲基钴胺素活性形式。恶性贫血患者体内可观测到维生素B12吸收受阻。维生素B12对成红细胞发育至关重要。妊娠会导致维生素B12水平下降。衰老会到维生素B12吸收减少。它可充当脂肪、碳水化合物和蛋白质代谢中的辅酶。它是细胞生长、遗传稳定性和体外存活必需的成分。参与支持一碳代谢。存在于许多经典和无血清配方中。

儲存類別代碼

11 - Combustible Solids

水污染物質分類(WGK)

WGK 1

個人防護裝備

Eyeshields, Gloves, type N95 (US)


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