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等級
pharmaceutical primary standard
API 家族
cetirizine
製造商／商標名
EDQM
應用
pharmaceutical (small molecule)
格式
neat
SMILES 字串
OC(COCCN1CCN(C(C2=CC=C(Cl)C=C2)C3=CC=CC=C3)CC1)=O.[H]Cl.[H]Cl
InChI
1S/C21H25ClN2O3.2ClH/c22-19-8-6-18(7-9-19)21(17-4-2-1-3-5-17)24-12-10-23(11-13-24)14-15-27-16-20(25)26;;/h1-9,21H,10-16H2,(H,25,26);2*1H
InChI 密鑰
PGLIUCLTXOYQMV-UHFFFAOYSA-N
基因資訊
human ... HRH1(3269)
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一般說明
This product is provided as delivered and specified by the issuing Pharmacopoeia. All information provided in support of this product, including SDS and any product information leaflets have been developed and issued under the Authority of the Issuing Pharmacopoeia. For further information and support please go to the website of the issuing Pharmacopoeia.
應用
Cetirizine dihydrochloride EP Reference standard, intended for use in laboratory tests only as specifically prescribed in the European Pharmacopoeia.
生化／生理作用
Cetirizine hydrochloride is an orally active and selective H1-receptor antagonist. Antihistaminic; Piperazines. Non-sedating type histamine H1-receptor antagonist; major metabolite of hydroxyzine. Pharmacological activity resides primarily in the (R)-isomer.
包裝
The product is delivered as supplied by the issuing Pharmacopoeia. For the current unit quantity, please visit the EDQM reference substance catalogue.
其他說明
Sales restrictions may apply.
Agnieszka Biedroł et al.
Pediatrics, 133(4), e1068-e1071 (2014-03-26)
The occurrence of stabbing headaches in children requires a thorough diagnostic approach that excludes secondary headaches. The organic background should be taken into consideration when alarming symptoms occur, such as a purely 1-sided location, a change in the character of
Céline Caillet et al.
British journal of clinical pharmacology, 74(5), 886-889 (2012-03-13)
The physicochemical properties of racemates and stereoisomers of medicines can differ significantly, and this may affect the side-effect profile in addition to the pharmacokinetics and intended pharmacology. This is a study to investigate the profile of adverse drug reactions of
Joya S Griffin et al.
The Canadian veterinary journal = La revue veterinaire canadienne, 53(1), 47-50 (2012-07-04)
Cetirizine hydrochloride was administered orally at 5 mg/cat, q24h, to 32 cats with allergic skin disease. Pruritus was reduced in 41% (13/32) of the cats. The antipruritic effect was repeatable and sustainable. There was no significant association between patient age
Benno Brinkhaus et al.
Annals of internal medicine, 158(4), 225-234 (2013-02-20)
Chinese translation Acupuncture is frequently used to treat seasonal allergic rhinitis (SAR) despite limited scientific evidence. To evaluate the effects of acupuncture in patients with SAR. Randomized, controlled multicenter trial. (ClinicalTrials.gov: NCT00610584) 46 specialized physicians in 6 hospital clinics and
Arnold Bahlmann et al.
Chemosphere, 89(11), 1278-1286 (2012-06-12)
Carbamazepine (CBZ), caffeine and cetirizine were monitored by enzyme-linked immunosorbent assays (ELISAs) in surface and wastewaters from Berlin, Germany. This fast and cost-efficient method enabled to assess the spatial and temporal variation of these anthropogenic markers in a high-throughput screening.
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