45674

红霉素

tested according to Ph. Eur.

• 别名: 红霉素
• 经验公式（希尔记法）: C₃₇H₆₇NO₁₃
• CAS号: 114-07-8
• 分子量: 733.93
• Beilstein: 75279
• EC號碼: 204-040-1
• MDL號碼: MFCD00084654
• 分類程式碼代碼: 51282304
• PubChem物質ID: 329756889
• NACRES: NA.76

属性

• agency: EPA 1694; USP/NF; tested according to Ph. Eur.
• 品質等級: 200
• 形狀: solid
• 顏色: white to faint yellow
• 溶解度: H₂O: soluble 2 mg/mL; acetone: freely soluble; acetonitrile: freely soluble; alcohol: soluble; amyl acetate: moderately soluble; chloroform: soluble; diethyl ether: soluble; ethyl acetate: freely soluble
• 抗生素活性譜: Gram-negative bacteria; Gram-positive bacteria
• 應用: environmental
• 作用方式: protein synthesis | interferes
• SMILES 字串: CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@@](C)(OC)[C@@H](O)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]3O[C@H](C)C[C@@H]([C@H]3O)N(C)C)[C@](C)(O)C[C@@H](C)C(=O)[C@H](C)[C@@H](O)[C@]1(C)O
• InChI: 1S/C37H67NO13/c1-14-25-37(10,45)30(41)20(4)27(39)18(2)16-35(8,44)32(51-34-28(40)24(38(11)12)15-19(3)47-34)21(5)29(22(6)33(43)49-25)50-26-17-36(9,46-13)31(42)23(7)48-26/h18-26,28-32,34,40-42,44-45H,14-17H2,1-13H3/t18-,19-,20+,21+,22-,23+,24+,25-,26+,28-,29+,30-,31+,32-,34+,35-,36-,37-/m1/s1
• InChI 密鑰: ULGZDMOVFRHVEP-RWJQBGPGSA-N
• 基因資訊: human ... ABCB1(5243) , CYP3A4(1576) , MLNR(2862) ; mouse ... Abcb1a(18671) , Abcb1b(18669)

说明

一般說明

Chemical structure: macrolide

應用

Erythromycin is an antibiotic produced by growth of certain strains of Streptomyces erythreus. This product is composed largely of erythromycin A with small amounts of erythromycins B and C and is recommended for concentration at 100 mg/L. Concentrations between 50 and 200 mg/L have also proven effective in controlling bacterial growth. Erythromycin has been used as a motilin receptor agonist, to block respiratory glycoconjugate secretion in human airways in vitro††, and for selecting plasmid-cured and recombinant lactococcus lactis MG1363 strains.

生化／生理作用

作用机制: 红霉素通过在转肽步骤中抑制延伸起作用，特别是通过结合细菌70S rRNA复合物的50S亚单位来抑制氨酰从A位点到P位点的易位。

抗菌谱：该产品可以抗革兰氏阴性和革兰氏阳性细菌。

包裝

25g

注意

This product is stable in solution at 37°C for 3 days. Stock solutions should be stored at 2-8°C.

準備報告

This product is soluble in water at 2 mg/mL, with a 0.067% solution in water yielding a pH of 8.0-10.5. It is also soluble in ethanol at 50 mg/mL, yielding a clear, colorless to faint yellow solution. It is freely soluble in alcohol, acetone, chloroform, acetonitrile and ethyl acetate but forms salts with acids. All solutions should be protected from light.

其他說明

Keep container tightly closed in a dry and well-ventilated place.

安全信息

• 儲存類別代碼: 11 - Combustible Solids
• 水污染物質分類（WGK）: WGK 3
• 閃點（°F）: Not applicable
• 閃點（°C）: Not applicable
• 個人防護裝備: Eyeshields, Gloves, type N95 (US)