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應用
cell analysis
一般說明
Mammary epithelial cells are a model for cellular plasticity, the ability to undergo varied morphological changes. One of the significant aspects of mammary-derived tumors is epithelial-to-mesenchymal transition (EMT), which gives rise to the migratory behavior required for metastasis (1). Cellular plasticity makes mammary epithelial cell models valuable for the study of breast cancer malignancy in addition to hormonal regulation of differentiation and epithelial cell polarization.
Eph4 is a spontaneously immortalized cell line derived from primary murine mammary epithelial cells (2). EpH4 cells can be induced to synthesize milk proteins, such as caseins, upon the induction with lactogenic hormones such as prolactin, hydrocortisone, and insulin. For normal maintenance Eph4 cells should be cultured at high density (semi-confluency) and passaged before reaching confluency to avoid polarization and selective culture of single cells. Post-confluent Eph4 cells undergo polarization and formation of hemicysts or dome-like structures characterized by unidirectional transport of ions (3).
<bold>Source:</bold>
Eph4 cell line is a spontaneously immortalized clone derived from primary mammary epithelial cells of a female BALB/c mouse.
Research Category:
Cancer
Eph4 is a spontaneously immortalized cell line derived from primary murine mammary epithelial cells (2). EpH4 cells can be induced to synthesize milk proteins, such as caseins, upon the induction with lactogenic hormones such as prolactin, hydrocortisone, and insulin. For normal maintenance Eph4 cells should be cultured at high density (semi-confluency) and passaged before reaching confluency to avoid polarization and selective culture of single cells. Post-confluent Eph4 cells undergo polarization and formation of hemicysts or dome-like structures characterized by unidirectional transport of ions (3).
<bold>Source:</bold>
Eph4 cell line is a spontaneously immortalized clone derived from primary mammary epithelial cells of a female BALB/c mouse.
Research Category:
Cancer
細胞系來源
Mouse, Epithelial Cells
包裝
≥1X106 cells/vial
儲存和穩定性
Store in liquid nitrogen. The cells can be cultured for at least 10 passages after initial thawing without significantly affecting the cell marker expression and functionality.
其他說明
This product is intended for sale and sold solely to academic institutions for internal academic research use per the terms of the “Academic Use Agreement” as detailed in the product documentation. For information regarding any other use, please contact licensing@emdmillipore.com.
免責聲明
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
儲存類別代碼
10 - Combustible liquids
水污染物質分類（WGK）
WGK 1
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