MABS456

Anti-PTP1B Antibody (Oxidized), clone scFvs 45

clone scFvs 45, from chicken

• 别名: Tyrosine-protein phosphatase non-receptor type 1, Protein-tyrosine phosphatase 1B, PTP-1B
• 分類程式碼代碼: 12352203
• eCl@ss: 32160702
• NACRES: NA.41

属性

• 生物源: chicken
• 品質等級: 100
• 抗體表格: purified antibody
• 抗體產品種類: primary antibodies
• 無性繁殖: scFvs 45, monoclonal
• 物種活性: human
• 技術: immunoprecipitation (IP): suitable
• NCBI登錄號: NP_002818
• UniProt登錄號: P18031
• 運輸包裝: wet ice
• 目標翻譯後修改: unmodified
• 基因資訊: human ... PTPN1(5770)

说明

一般說明

PTP1B is the prototypic member of the protein tyrosine phosphatase (PTP) family, which comprises at least 37 proteins. The family is characterized by a catalytic phosphatase domain of approximately 240 amino acids, and includes both transmembrane and cytosolic enzymes. The PTPs have high substrate specificity for phosphotyrosyl proteins. At the primary sequence level, PTPs share little similarity with the protein serine phosphatases, protein threonine phosphatases, or the acid and alkaline phosphatases. PTP1B is a negative regulator of insulin and leptin signal transduction and may be a potential therapeutic target for diabetes and obesity. Insulin also influences the expression of splice variants of PTP1B.

特異性

This antibody only reacts with the oxidized form.

免疫原

Epitope: PTP1B-OX

Recombinant protein corresponding to the PTP1B-OX of human PTP1B (Oxidized).

應用

Anti-PTP1B Antibody (Oxidized), clone scFvs 45 | MABS456 is an antibody against PTP1B Antibody for use in Immunoprecipitation, Inhibits Activity/Function.

Immunoprecipitation Analysis: This antibody immunoprecipitated PTP1B (Oxidized) recombinant (aa 1-321; WT and CASA mutant) (Haque, A., et al. (2011). Cell. 147:185-198).
Immunoprecipitation Analysis: This antibody immunoprecipitated PTP1B (Oxidized) recombinant (aa 1-321; WT and CASA mutant) (Haque, A., et al. (2012). Nature America. 7(12):2127-2143).
Inhibits Activity/Function Analysis: A representative lot detected PTP1B (Oxidized) in recombinant PTP1B (aa 1-321; WT and CASA mutant) and scFv45) (Haque, A., et al. (2011). Cell. 147:185-198).
Inhibits Activity/Function Analysis: A representative lot detected PTP1B (Oxidized) in recombinant PTP1B (aa 1-321; WT and CASA mutant)and scFv45) (Haque, A., et al. (2012). Nature America. 7(12):2127-2143).

Research Category
Signaling

Research Sub Category
Signaling Neuroscience

品質

Evaluated by Immunoprecipitation in recombinant PTP1B (aa 1-321; WT and CASA mutant) and scFv45 cell lysate.

Immunoprecipitation Analysis: 278 ng of this antibody detected PTP1B (Oxidized) in recombinant PTP1B (aa 1-321; WT and CASA mutant) and scFv45 cell lysate.

標靶描述

~37 kDa observed. The calculated molecular weight is 50kDa however PTP1B has been observed at ~37 kDa since it is a truncated form (aa 1-321). Uncharacterized band(s) may appear in some lysates.

聯結

Replaces: 04-1140

外觀

Ni-NTA agarose

Format: Purified

Purified chicken monoclonal in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.

儲存和穩定性

Stable for 1 year at 2-8°C from date of receipt.

其他說明

Concentration: Please refer to lot specific datasheet.

免責聲明

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

安全信息

• 儲存類別代碼: 12 - Non Combustible Liquids
• 水污染物質分類（WGK）: WGK 1
• 閃點（°F）: Not applicable
• 閃點（°C）: Not applicable