推荐产品
生物源
mouse
品質等級
抗體表格
purified immunoglobulin
抗體產品種類
primary antibodies
無性繁殖
monoclonal
物種活性
human, mouse, rat
製造商／商標名
Chemicon®
技術
ELISA: suitable
western blot: suitable
同型
IgG1
NCBI登錄號
UniProt登錄號
運輸包裝
wet ice
目標翻譯後修改
unmodified
基因資訊
human ... CREB1(1385)
一般說明
CREB is a beta ZIP transcription factor that activates target genes through cAMP response elements. CREB is able to mediate signals from numerous physiological stimuli, resulting in regulation of a broad array of cellular responses. While CREB is expressed in numerous tissues, it plays a large regulatory role in the nervous system. CREB is believed to play a key role in promoting neuronal survival, precursor proliferation, neurite outgrowth and neuronal differentiation in certain neuronal populations. CREB promotes outgrowth and differentiation as a mediator of Neurotrophin pathways. CREB is able to selectively activate numerous downstream genes through interactions with different dimerization partners. CREB is activated by phosphorylation at Ser133 by various signaling pathways including Erk, Ca2+ and stress signaling.
特異性
Reacts with CREB.
免疫原
Recombinant CREB-A protein.
應用
Anti-CREB Antibody is a Mouse Monoclonal Antibody for detection of CREB also known as cAMP-response Element Binding Protein & has been validated in ELISA & WB.
Research Category
Epigenetics & Nuclear Function
Epigenetics & Nuclear Function
Research Sub Category
Transcription Factors
Transcription Factors
Western blot: 1-5 μg/mL. Recognizes the ~43kDa protein.
ELISA: 0.1-1.0 μg/mL
Optimal working dilutions must be determined by end user.
ELISA: 0.1-1.0 μg/mL
Optimal working dilutions must be determined by end user.
聯結
Replaces: 04-218
外觀
Format: Purified
Purified immunoglobulin. Liquid in PBS containing 0.1% sodium azide.
儲存和穩定性
Maintain at 2-8°C in undiluted aliquots for up to 6 months after date of receipt.
分析報告
Control
Jurkat nuclear extract, A-431 whole cell lysate
Jurkat nuclear extract, A-431 whole cell lysate
其他說明
Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration.
法律資訊
CHEMICON is a registered trademark of Merck KGaA, Darmstadt, Germany
免責聲明
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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儲存類別代碼
12 - Non Combustible Liquids
水污染物質分類（WGK）
WGK 2
閃點（°F）
Not applicable
閃點（°C）
Not applicable
Stimulated neuronal expression of brain-derived neurotrophic factor by Neurotropin.
Yu Fukuda,Thomas L Berry,Matthew Nelson,Christopher L Hunter,Koki Fukuhara,Hideki Imai et al.
Molecular and Cellular Neurosciences null
Hong Cao et al.
Neuroscience bulletin, 28(1), 77-87 (2012-01-12)
The rostral anterior cingulate cortex (rACC) is implicated in processing the emotional component of pain. N-methyl-D-aspartate receptors (NMDARs) are highly expressed in the rACC and mediate pain-related affect by activating a signaling pathway that involves cyclic adenosine monophosphate (cAMP)/protein kinase
Yan-Yan Sun et al.
Scientific reports, 6, 30743-30743 (2016-08-05)
The number and subtype composition of N-methyl-d-aspartate receptor (NMDAR) at synapses determines their functional properties and role in learning and memory. Genetically increased or decreased amount of GluN2B affects hippocampus-dependent memory in the adult brain. But in some experimental conditions
Increasing CREB function in the CA1 region of dorsal hippocampus rescues the spatial memory deficits in a mouse model of Alzheimer's disease.
Yiu, AP; Rashid, AJ; Josselyn, SA
Neuropsychopharmacology null
Identification of drug candidates which increase cytochrome c oxidase activity in deficient patient fibroblasts.
Maj M, Sriskandarajah N, Hung V, Browne I, Shah B, Weadge A, Jamieson NL, Tropak M et al.
Mitochondrion null
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