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Key Documents

IM1014

Sigma-Aldrich

Anti-Matriptase/MT-SP1 Rabbit pAb

liquid, Calbiochem®

别名:

Anti-Membrane-Type Serine Protease 1, Anti-Suppressor of Tumorgenicity 14

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About This Item

分類程式碼代碼:
12352203
NACRES:
NA.41

生物源

rabbit

品質等級

抗體表格

affinity isolated antibody

抗體產品種類

primary antibodies

無性繁殖

polyclonal

形狀

liquid

包含

≤0.1% sodium azide as preservative

物種活性

human

製造商/商標名

Calbiochem®

儲存條件

OK to freeze

同型

IgG

運輸包裝

wet ice

儲存溫度

2-8°C

目標翻譯後修改

unmodified

基因資訊

human ... ST14(6768)

一般說明

Immunoaffinity purified rabbit polyclonal antibody. Recognizes the ~75 kDa matriptase protein.
Recognizes the ~75 kDa matriptase protein in MCF-7 cells.
This Anti-Matriptase/MT-SP1 Rabbit pAb is validated for use in Immunoblotting, Immunoprecipitation for the detection of Matriptase/MT-SP1.

免疫原

Human
a synthetic peptide corresponding to amino acids near the C-terminus of human matriptase

應用


Immunoblotting (1:500-1:2000)
Immunoprecipitation (5-20 g/mg lysate)

包裝

Please refer to vial label for lot-specific concentration.

警告

Toxicity: Highly Toxic (H)

外觀

In Tris-citrate/phosphate buffer, pH 7.0-8.0.

重構

Following initial use, aliquot and freeze (-20°C) for long-term storage. Avoid freeze/thaw cycles.

分析報告

Positive Control
MCF-7 cells

其他說明

Antibody should be titrated for optimal results in individual systems.
Santin, A.D., et al. 2003. Cancer98, 1898.
Takeuchi, T., et al. 2000. J. Biol. Chem.275, 26333.
Lin, C.Y., et al. 1999. J. Biol. Chem.274, 18231.
Takeuchi, T., et al. 1999. Proc. Natl. Acad. Sci. USA96, 11054.

法律資訊

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

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儲存類別代碼

10 - Combustible liquids

水污染物質分類(WGK)

WGK 1

閃點(°F)

Not applicable

閃點(°C)

Not applicable


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Sine Godiksen et al.
PloS one, 8(10), e77146-e77146 (2013-11-10)
Matriptase is a member of the family of type II transmembrane serine proteases that is essential for development and maintenance of several epithelial tissues. Matriptase is synthesized as a single-chain zymogen precursor that is processed into a two-chain disulfide-linked form
Ke-Hung Tsui et al.
Journal of molecular endocrinology, 49(2), 153-163 (2012-08-09)
Growth differentiation factor-15 (GDF15), a member of the transforming growth factor-β superfamily, is associated with human cancer progress. We evaluated the role GDF15 plays in tumorigenesis of prostate carcinoma PC-3 cells. Results from real-time RT-PCR and ELISA revealed that expression
Jennifer M Milner et al.
Arthritis and rheumatism, 62(7), 1955-1966 (2010-05-28)
Increasing evidence implicates serine proteinases in pathologic tissue turnover. The aim of this study was to assess the role of the transmembrane serine proteinase matriptase in cartilage destruction in osteoarthritis (OA). Serine proteinase gene expression in femoral head cartilage obtained
Marguerite S Buzza et al.
The Journal of biological chemistry, 292(26), 10801-10812 (2017-05-12)
Compromised gastrointestinal barrier function is strongly associated with the progressive and destructive pathologies of the two main forms of irritable bowel disease (IBD), ulcerative colitis (UC), and Crohn's disease (CD). Matriptase is a membrane-anchored serine protease encoded by suppression of
Sine Godiksen et al.
The Biochemical journal, 413(2), 251-259 (2008-04-12)
HAI-1 [HGF (hepatocyte growth factor) activator inhibitor-1] is a Kunitz-type transmembrane serine protease inhibitor that forms inhibitor complexes with the trypsin-like serine protease, matriptase. HAI-1 is essential for mouse placental development and embryo survival and together with matriptase it is

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