8.55117

Hydroxylamine Wang resin

Novabiochem^®

• 别名: Amino-oxy Wang resin
• 分類程式碼代碼: 12352116
• NACRES: NA.22

属性

• 品質等級: 200
• 產品線: Novabiochem^®
• 形狀: beads
• 反應適用性: reaction type: Fmoc solid-phase peptide synthesis
• 製造商／商標名: Novabiochem^®
• 應用: peptide synthesis
• 儲存溫度: 2-8°C

说明

一般說明

An excellent support for the preparation of peptide hydroxamic acids ^[1] by Fmoc SPPS. Acylation of the resin has been carried out using TBTU/DIPEA activation ^[1]. Alkylation of the resin-bound nitrogen has been effected using TMOF/DCE/AcOH for imine formation, followed by reduction with BH₃-pyridine ^[2], by base-mediated alkylation of the N-Boc-protected hydroxylamine, followed by Boc removal with 20% TFA in DCM ^[3], or by Michael-addition ^[4]. Cleavage of hydroxamates from the resin has been effected with TFA/DCM/water (70:28:2) ^[1] or TFA/DCM (1:1) ^[2]. Hydroxylamine Wang resin has also been utilized to prepare tertiary amines by base-mediated elimination of the quaternized polymer-bound hydroxylamine ^{[3, 5]}.

Associated Protocols and Technical Articles
Protocols for Loading of Peptide Synthesis Resins

Literature references

^[1] C. D. Floyd, et al. (1996) Tetrahedron Lett., 37, 8045.
^[2] D. E. Robinson & M. W. Holladay (2000) Org. Lett., 2, 2777.
^[3] P. Blaney, et al. (2000) Tetrahedron Lett., 41, 6635.
^[4] A. Volonterio, et al. (2002) Eur. J. Org. Chem., 428.
^[5] P. Blaney, et al. (2000) Tetrahedron Lett., 41, 6639.

聯結

Replaces: 01-64-0454

分析報告

Color (visual): white to yellow to beige
Appearance of substance (visual): beads
Loading (determined by elemental analysis of nitrogen): 1.5 - 2.5 mmol/g
Swelling Volume (in DMF): lot specific result
The polymer matrix is copoly (styrene - 1% DVB), 100 - 200 mesh.

法律資訊

Novabiochem is a registered trademark of Merck KGaA, Darmstadt, Germany

安全信息

• 儲存類別代碼: 11 - Combustible Solids
• 水污染物質分類（WGK）: WGK 1
• 閃點（°F）: Not applicable
• 閃點（°C）: Not applicable