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Merck
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Key Documents

8.55061

Sigma-Aldrich

HMPB-MBHA resin

Novabiochem®

别名:

4-Hydroxymethyl-3-methoxyphenoxybutyric acid MBHA resin

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About This Item

分類程式碼代碼:
13111023
NACRES:
NA.22

品質等級

200

產品線

Novabiochem®

形狀

beads

反應適用性

reaction type: Fmoc solid-phase peptide synthesis

製造商／商標名

Novabiochem®

應用

peptide synthesis

官能基

alcohol

儲存溫度

2-30°C

相关类别

一般說明

This support consists of MBHA resin functionalized with Riniker′s hyperacid-labile 4-hydroxymethyl-3-methoxyphenoxybutyric acid linker [1].This hyperacid-sensitive resin is a useful tool for the Fmoc SPPS of protected peptide acid fragments. Attachment of carboxylic acids is normally achieved by DMAP catalyzed esterification with the appropriate symmetrical anhydride, or by using 2,6-dichlorobenzoylchloride/pyridine [2] or MSNT/Melm activation [3,4,5].Detachment of these functionalities can be effected by treatment with 1-5% TFA in DCM.

Associated Protocols and Technical Articles
Protocols for Loading of Peptide Synthesis Resins

聯結

Replaces: 01-64-0036

分析報告

Colour (visual): white to yellow to beige
Appearance of substance (visual): beads
Loading (determined from the substitution of the Fmoc-Leu loaded resin): 0.40 - 1.00 mmol/g
Swelling Volume (in DMF): lot specific result
The polymer matrix is copoly ( styrene - 1% DVB ) 100- 200 mesh

法律資訊

Novabiochem is a registered trademark of Merck KGaA, Darmstadt, Germany

儲存類別代碼

11 - Combustible Solids

水污染物質分類（WGK）

WGK 1

閃點（°F）

Not applicable

閃點（°C）

Not applicable

分析证书(COA)

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商品

Boc Resin Cleavage and Deprotection

The most popular reagent for cleavage of peptides from Boc-based resins is anhydrous HF. Of all the cleavage procedures HF appears to be the most versatile and least harmful to a wide variety of peptides synthesized on Boc-based resins.

Linkers for Fmoc SPPS

Novabiochem® has one of the most extensive ranges of linkers and derivatized resins for Fmoc solid phase peptide synthesis. These resins have varied properties with special protocols for loading and cleaving.

Linkers for Fmoc SPPS

Novabiochem® has one of the most extensive ranges of linkers and derivatized resins for Fmoc solid phase peptide synthesis. These resins have varied properties with special protocols for loading and cleaving.

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