推荐产品
product name
TLR3/dsRNA复合物抑制剂, The TLR3/dsRNA Complex Inhibitor blocks dsRNA binding to TLR3.
品質等級
化驗
≥99% (HPLC)
形狀
solid
製造商／商標名
Calbiochem®
儲存條件
OK to freeze
protect from light
顏色
white
溶解度
DMSO: 50 mg/mL
運輸包裝
wet ice
儲存溫度
2-8°C
一般說明
噻吩甲酰胺基丙酸酯化合物可作为直接竞争性和高亲和力抑制剂，抑制dsRNA和TLR3的结合（Ki = 2.96 µM；dsRNA结合TLR3的Kd = 19 nM），同时其可选择性拮抗经刺激的TLR3信号转导，且不会影响TLR1/2、TLR2/6、TLR4和TLR7途径。在Poly（I：C）诱导的RAW 264.7巨噬细胞中，其显示出可有效抑制TNF-α和IL-1β（IC90 = 27 µM）和NO的产生（IC50 = 3.44 µM）。其表现出最小的细胞毒性（在RAW 264.7细胞中IC50 >>100 µM），并对一组12种代表性激酶和4种细胞色素酶的活性有较弱的抑制作用（体外分析）。
包裝
用惰性气体包装
警告
毒性：标准处理（A）
其他說明
Cheng, K., et al. 2011.J. Am. Chem. Soc.133, 3764.
法律資訊
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
儲存類別代碼
11 - Combustible Solids
水污染物質分類（WGK）
WGK 1
閃點（°F）
Not applicable
閃點（°C）
Not applicable
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