推荐产品
product name
SHP1/2蛋白酪氨酸磷酸酶抑制剂，NSC-87877, The SHP1/2 PTPase Inhibitor, NSC-87877, also referenced under CAS 56932-43-5, controls the biological activity of SHP1/2 PTPase. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylation applications.
品質等級
化驗
≥97% (HPLC)
形狀
solid
製造商／商標名
Calbiochem®
儲存條件
OK to freeze
desiccated (hygroscopic)
protect from light
顏色
red-brown
溶解度
water: 10 mg/mL
運輸包裝
ambient
儲存溫度
2-8°C
InChI
1S/C19H13N3O7S2.2Na/c23-19-16(10-17(31(27,28)29)15-2-1-7-20-18(15)19)22-21-13-5-3-12-9-14(30(24,25)26)6-4-11(12)8-13;;/h1-10,21H,(H,24,25,26)(H,27,28,29);;/q;2*+1/p-2/b22-16+;;
InChI 密鑰
YOGRUDWAJPVHEL-LLDDCTHSSA-L
一般說明
一种细胞渗透性7-氮杂-8-羟基喹啉化合物，作为SHP-1和SHP-2蛋白酪氨酸磷酸酶的有效催化靶向抑制剂（IC50分别为355 nM和318 nM）。它抑制PTP1B和HePTP的效力较低（IC50分别为1.69 µM和7.75 µM），并且比DEP1、CD45和LAR表现出>200倍的选择性。显示抑制HEK293细胞的基础和刺激SHP-2活性。
生化／生理作用
Cell permeable: yes
主要靶标
SHP1/2 PTPase
SHP1/2 PTPase
产物不与ATP竞争。
可逆：否
靶标IC50：针对SHP-1和SHP-2蛋白酪氨酸磷酸酶分别为355 nM和318 nM
包裝
用惰性气体包装
警告
毒性：标准处理（A）
重構
复溶后，等分并冷冻保存（-20°C）。贮备溶液在-20°C下可稳定保存至多3个月。
其他說明
Chen, L., et al. 2006.Mol.Pharmacol.70, 562.
法律資訊
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
儲存類別代碼
11 - Combustible Solids
水污染物質分類（WGK）
WGK 2
閃點（°F）
Not applicable
閃點（°C）
Not applicable
Sofía C Khouili et al.
Cell reports, 33(9), 108468-108468 (2020-12-03)
Intracellular pathogens have evolved strategies to evade detection by cytotoxic CD8+ T lymphocytes (CTLs). Here, we ask whether Leishmania parasites trigger the SHP-1-FcRγ chain inhibitory axis to dampen antigen cross-presentation in dendritic cells expressing the C-type lectin receptor Mincle. We
Corleone S Delaveris et al.
ChemRxiv : the preprint server for chemistry (2021-01-21)
Severe cases of coronavirus disease 2019 (COVID-19), caused by infection with SARS-Cov-2, are characterized by a hyperinflammatory immune response that leads to numerous complications. Production of proinflammatory neutrophil extracellular traps (NETs) has been suggested to be a key factor in
Paul R C Imbert et al.
Current biology : CB, 31(1), 77-89 (2020-10-24)
Macrophages continuously survey their environment in search of pathogens or apoptotic corpses or debris. Targets intended for clearance expose ligands that initiate their phagocytosis ("eat me" signals), while others avoid phagocytosis by displaying inhibitory ligands ("don't eat me" signals). We
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