530050-M

PRIMA-1

A cell-permeable quinuclidinone analog with antitumor properties.

• 别名: PRIMA-1, 2,2-Bis(hydroxymethyl)-1-azabicyclo[2,2,2]octan-3-one, p53 Reactivation and Induction of Massive Apoptosis
• 经验公式（希尔记法）: C₉H₁₅NO₃
• CAS号: 5608-24-2
• 分子量: 185.22
• MDL號碼: MFCD04974196
• 分類程式碼代碼: 12352200

属性

• 品質等級: 100
• 化驗: ≥95% (NMR)
• 形狀: solid
• 製造商／商標名: Calbiochem^®
• 儲存條件: OK to freeze; desiccated (hygroscopic)
• 顏色: off-white
• 溶解度: water: 2 mg/mL
• 儲存溫度: 2-8°C
• InChI: 1S/C9H15NO3/c11-5-9(6-12)8(13)7-1-3-10(9)4-2-7/h7,11-12H,1-6H2
• InChI 密鑰: RFBVBRVVOPAAFS-UHFFFAOYSA-N

说明

一般說明

A cell-permeable quinuclidinone analog with anti-tumor properties. Induces p53-dependent apoptosis in human tumor cells through restoration of the transcriptional transactivation function to mutant p53. Restores sequence-specific DNA binding and active conformation to mutant p53 proteins in vitro and in living cells. Suppresses tumor growth in mice with no apparent toxicity. Induces apoptosis in breast cancer cells expressing mutant p53.

A cell-permeable quinuclidinone analog with antitumor properties. Restores biochemical and biological function to mutant p53 and induces p53-dependent apoptosis in vitro and in vivo. Induces apoptosis in breast cancer cells expressing mutant p53.

生化／生理作用

Primary Target
Restores biochemical and biological function to mutant p53

警告

Toxicity: Standard Handling (A)

其他說明

Bykov, V.J., et al. 2002. Nat. Med.8, 282.

法律資訊

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

安全信息

• 象形圖: GHS08,GHS07
• 訊號詞: Danger
• 危險聲明: H302,H334
• 防範說明: P261 - P264 - P270 - P284 - P301 + P312 - P501
• 危險分類: Acute Tox. 4 Oral - Resp. Sens. 1
• 儲存類別代碼: 11 - Combustible Solids
• 水污染物質分類（WGK）: WGK 3
• 閃點（°F）: Not applicable
• 閃點（°C）: Not applicable