5.06238

氢溴酸西酞普兰 氢溴酸盐

• 别名: 1-[3-（二甲氨基）丙基]-1-（4-氟苯基）-1,3-二氢-5-异苯并呋喃甲腈 氢溴酸盐
• 经验公式（希尔记法）: C₂₀H₂₁FN₂O · HBr
• CAS号: 59729-32-7
• 分子量: 405.30
• MDL號碼: MFCD02101306
• 分類程式碼代碼: 12352200
• NACRES: NA.77

属性

• 化驗: ≥98% (HPLC)
• 品質等級: 100
• 形狀: solid
• 效力: 1.8 nM IC₅₀
• 製造商／商標名: Calbiochem^®
• 儲存條件: OK to freeze; protect from light
• 顏色: white
• 溶解度: water: 10 mM; ethanol: 50 mM
• 儲存溫度: 2-8°C
• SMILES 字串: Br[H].CN(C)CCCC1(OCc2cc(ccc12)C#N)c3ccc(F)cc3
• InChI: 1S/C20H21FN2O.BrH/c1-23(2)11-3-10-20(17-5-7-18(21)8-6-17)19-9-4-15(13-22)12-16(19)14-24-20;/h4-9,12H,3,10-11,14H2,1-2H3;1H
• InChI 密鑰: WIHMBLDNRMIGDW-UHFFFAOYSA-N

说明

一般說明

A potent uptake inhibitor highly selective for 5-HT transporter without effect on noradrenalin or dopamine uptake (IC₅₀ = 1.8, 8800 and 41000 nM for 5-HT, noradrenalin and dopamine, respectively). Clinically prescribed as an antidepressant drug. Widely used in research related to depressive disorders.

生化／生理作用

有效的选择性 5-羟色胺摄取抑制剂 (K_i = 5.4 nM)；抗抑郁药

Primary Target
5-HT Transporter

警告

Toxicity: Harmful (C)

重構

Following reconstitution, aliquot and freeze (-20°). Stock solutions are stable for up to 3 months at -20°C.

其他說明

Garriock, A., et al., 2010. Bio. Psychiatry.67, 133.
Gabriel, J.P., et al. 2009. J. Neurosci.29,10387.
Torres, G.E., et al. 2003. Nat. Rev. Neurosci.4, 13.

法律資訊

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

安全信息

• 象形圖: GHS07,GHS08
• 訊號詞: Warning
• 危險聲明: H302 - H336 - H361d - H412
• 防範說明: P202 - P261 - P264 - P273 - P301 + P312 - P308 + P313
• 危險分類: Acute Tox. 4 Oral - Aquatic Chronic 3 - Repr. 2 - STOT SE 3
• 標靶器官: Central nervous system
• 儲存類別代碼: 11 - Combustible Solids
• 水污染物質分類（WGK）: WGK 2
• 閃點（°F）: Not applicable
• 閃點（°C）: Not applicable