476485
PKA抑制剂14-22酰胺，细胞可渗透，豆蔻酰化
PKA Inhibitor 14-22 Amide is myristoylated at the N-terminus that enhances its cell-permeability. The non-myristoylated version is shown to be a specific inhibitor of PKA (Ki = 36 nM).
别名:
PKA抑制剂14-22酰胺，细胞可渗透，豆蔻酰化
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About This Item
经验公式（希尔记法）:
C53H100N20O12
分子量:
1209.49
分類程式碼代碼:
12352200
NACRES:
NA.77
推荐产品
品質等級
化驗
≥95% (HPLC)
形狀
lyophilized
製造商／商標名
Calbiochem®
儲存條件
OK to freeze
desiccated (hygroscopic)
溶解度
water: 1 mg/mL
運輸包裝
ambient
儲存溫度
−20°C
一般說明
热稳定的蛋白激酶抑制剂（PKI）肽序列（14-22），在N端已被肉豆蔻酰化，增强了其细胞通透性。该肽的非肉豆蔻酰化形式是cAMP依赖性蛋白激酶的高度特异性抑制剂（Ki=36 nM）。
热稳定的蛋白激酶抑制剂（PKI）肽序列（14-22），在N端已被肉豆蔻酰化，增强了其细胞通透性。该肽的非肉豆蔻酰化形式是cAMP依赖性蛋白激酶（PKA）的高度特异性抑制剂（Ki=36 nM）。
生化／生理作用
主要靶标
cAMP依赖性蛋白激酶
cAMP依赖性蛋白激酶
产物不与ATP竞争。
可逆：否
细胞可渗透性：具有
靶标Ki：36 nMf或cAMP依赖性蛋白激酶
警告
毒性：标准处理（A）
序列
Myr-N-Gly-Arg-Thr-Gly-Arg-Arg-Asn-Ala-Ile-NH₂
外觀
作为三氟乙酸盐提供。
重構
复溶后，等分并冷冻保存（-20°C）。贮备液在-20°C下可稳定保存至多3个月。
其他說明
Paman, K., et al. 1998.J. Lipid Res. 39, 1091.
Rimon, G., and Rubin M. 1998.Biochim.Biophys.Acta 1380, 289.
Harris, T.E., et al. 1997.Biochem.Biophys.Res. Commun.232, 648.
Muniz, M., et al. 1997.Proc.Natl.Acad.Sci. USA 94, 14461.
Zoukhri, D., et al. 1997.Am. J. Physiol.272, C263.
Eichholtz, T., et al. 1993.J. Biol. Chem.268, 1982.
Ward, N.E. and O’Brian, C.A.1993.Biochemistry32, 11903.
Walsh, D.A. and Glass, D.B.1991.Methods Enzymol.201, 304.
Glass, D.B., et al. 1989.J. Biol. Chem.264, 8802.
Rimon, G., and Rubin M. 1998.Biochim.Biophys.Acta 1380, 289.
Harris, T.E., et al. 1997.Biochem.Biophys.Res. Commun.232, 648.
Muniz, M., et al. 1997.Proc.Natl.Acad.Sci. USA 94, 14461.
Zoukhri, D., et al. 1997.Am. J. Physiol.272, C263.
Eichholtz, T., et al. 1993.J. Biol. Chem.268, 1982.
Ward, N.E. and O’Brian, C.A.1993.Biochemistry32, 11903.
Walsh, D.A. and Glass, D.B.1991.Methods Enzymol.201, 304.
Glass, D.B., et al. 1989.J. Biol. Chem.264, 8802.
法律資訊
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
儲存類別代碼
11 - Combustible Solids
水污染物質分類（WGK）
WGK 1
閃點（°F）
Not applicable
閃點（°C）
Not applicable
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