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Key Documents

474791

Sigma-Aldrich

MG-132

InSolution, ≥98%, 10 mM, reversible proteasome inhibitor

别名:

Z-Leu-Leu-Leu-al, InSolution MG-132, 碳苯并-L-亮氨酰-L-亮氨酰-L-亮氨酸,Z-LLL-CHO,蛋白酶体抑制剂XI, MG-132

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About This Item

经验公式(希尔记法):
C26H41N3O5
分子量:
475.62
MDL號碼:
分類程式碼代碼:
12352200
NACRES:
NA.77

品質等級

化驗

≥98% (HPLC)

形狀

liquid

製造商/商標名

Calbiochem®

儲存條件

OK to freeze
protect from light

運輸包裝

wet ice

儲存溫度

−20°C

SMILES 字串

[H]C(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(C)C)NC(=O)OCc1ccccc1

InChI

1S/C26H41N3O5/c1-17(2)12-21(15-30)27-24(31)22(13-18(3)4)28-25(32)23(14-19(5)6)29-26(33)34-16-20-10-8-7-9-11-20/h7-11,15,17-19,21-23H,12-14,16H2,1-6H3,(H,27,31)(H,28,32)(H,29,33)/t21-,22-,23-/m0/s1

InChI 密鑰

TZYWCYJVHRLUCT-VABKMULXSA-N

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Amino Acid Sequence

Z-Leu-Leu-Leu-al

一般說明

高效、可逆和细胞可透过性蛋白酶体抑制剂((Ki = 4 nM)。可通过26S复合物降低哺乳动物细胞和酵母可渗透菌株中泛素结合蛋白的降解,而不会影响其ATP酶或异肽酶的活性。可激活c-Jun N端激酶(JNK1)、抑制NF-κB的活化(IC50 = 3 µM)。

生化/生理作用

产品不与ATP竞争。
可逆性:是
细胞渗透性:是
靶标IC50:3 µM抑制NF-κB活化
靶标Ki:4 nM作为蛋白酶体抑制剂

包裝

用惰性气体包装

警告

毒性:刺激性(B)

外觀

10 mM(1 mg/210 µl)或(5 mg/1050 l)MG-132 DMSO溶液(货号474790)提供。

其他說明

Meriin, A.B., et al. 1998.J. Biol. Chem.273, 6373.
Adams, J., and Stein, R. 1996.Ann.Rep.Med. Chem.31, 279.
Lee, D.H., and Goldberg, A.L.1996.J. Biol. Chem.271, 27280.
Wiertz, E.J.H.J., et al. 1996.Cell84, 769.
Read, M.A., et al. 1995.Immunity2, 493.
Rock, K.L., et al. 1994.Cell78, 761.

法律資訊

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

儲存類別代碼

10 - Combustible liquids

水污染物質分類(WGK)

WGK 2

閃點(°F)

188.6 °F - closed cup - (Dimethylsulfoxide)

閃點(°C)

87 °C - closed cup - (Dimethylsulfoxide)


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E J Wiertz et al.
Cell, 84(5), 769-779 (1996-03-08)
Human cytomegalovirus (HCMV) down-regulates expression of MHC class I products by selective proteolysis. A single HCMV gene, US11, which encodes an endoplasmic reticulum (ER) resident type-I transmembrane glycoprotein, is sufficient to cause this effect. In US11+cells, MHC class I molecules
D H Lee et al.
The Journal of biological chemistry, 271(44), 27280-27284 (1996-11-01)
We have studied whether various agents that inhibit purified yeast and mammalian 26 S proteasome can suppress the breakdown of different classes of proteins in Saccharomyces cerevisiae. The degradation of short-lived proteins was inhibited reversibly by peptide aldehyde inhibitors of
Christina V Ernstsen et al.
Acta physiologica (Oxford, England), 234(2), e13760-e13760 (2022-01-04)
Aquaporin-2 (AQP2) shuttling between intracellular vesicles and the apical plasma membrane is pivotal in arginine vasopressin-mediated urine concentration and is dysregulated in multiple diseases associated with water balance disorders. Children and adults with acute pyelonephritis have a urinary concentration defect
A B Meriin et al.
The Journal of biological chemistry, 273(11), 6373-6379 (1998-04-16)
Inhibition of the major cytosolic protease, proteasome, has been reported to induce programmed cell death in several cell lines, while with other lines, similar inhibition blocked apoptosis triggered by a variety of harmful treatments. To elucidate the mechanism of pro-
Clarissa Braun et al.
Cell stress, 5(12), 176-182 (2021-12-18)
Programmed cell death protein 4 (PDCD4) exerts critical functions as tumor suppressor and in immune cells to regulate inflammatory processes. The phosphoinositide 3-kinase (PI3K) promotes degradation of PDCD4 via mammalian target of rapamycin complex 1 (mTORC1). However, additional pathways that

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