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Key Documents

474790

Sigma-Aldrich

MG-132

A cell-permeable, potent, reversible proteasome inhibitor (Ki = 4 nM).

别名:

Z-Leu-Leu-Leu-al, MG-132

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About This Item

经验公式(希尔记法):
C26H41N3O5
分子量:
475.62
MDL號碼:
分類程式碼代碼:
12352200
NACRES:
NA.77

品質等級

化驗

≥98% (HPLC)

形狀

solid

製造商/商標名

Calbiochem®

儲存條件

OK to freeze

顏色

white

溶解度

DMSO: 20 mg/mL
ethanol: 20 mg/mL

運輸包裝

ambient

儲存溫度

−20°C

SMILES 字串

[H]C(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(C)C)NC(=O)OCc1ccccc1

InChI

1S/C26H41N3O5/c1-17(2)12-21(15-30)27-24(31)22(13-18(3)4)28-25(32)23(14-19(5)6)29-26(33)34-16-20-10-8-7-9-11-20/h7-11,15,17-19,21-23H,12-14,16H2,1-6H3,(H,27,31)(H,28,32)(H,29,33)/t21-,22-,23-/m0/s1

InChI 密鑰

TZYWCYJVHRLUCT-VABKMULXSA-N

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Amino Acid Sequence

Z-Leu-Leu-Leu-al

一般說明

可通过26S复合物降低哺乳动物细胞和酵母可渗透菌株中泛素结合蛋白的降解,而不会影响其ATP酶或异肽酶的活性。可激活c-Jun N端激酶(JNK1),从而启动细胞凋亡。抑制NF-kB的活化(IC50 = 3 µM)。也有报道称,间充质干细胞移植后的存活率增加。
高效、可逆和细胞可透过性蛋白酶体抑制剂((Ki = 4 nM)。可通过26S复合物降低哺乳动物细胞和酵母可渗透菌株中泛素结合蛋白的降解,而不会影响其ATP酶或异肽酶的活性。可激活c-Jun N端激酶(JNK1),从而启动细胞凋亡。抑制NF-κB的活化(IC50 = 3 µM)。也有报道称,间充质干细胞移植后的存活率增加。防止β-分泌酶裂解。µ号474791)的DMSO溶液。HPLC法测定该物质纯度≥98%。一种物质,HPLC法测定的纯度≥95%(目录。

生化/生理作用

4 nM抗蛋白酶体
主要靶标
蛋白酶体
产品不与ATP竞争。
可逆性:是
细胞渗透性:是
靶标IC50:3 µM抑制NF-κB活化

警告

毒性:标准处理(A)

序列

Z-Leu-Leu-Leu-CHO

重構

溶解后,等分并冷冻保存(-20°C)。储备溶液在-20°C下可稳定保存1个月。

其他說明

Li, Z.W. et al. 2011.Sheng Li Xue Bao.63, 525.
Steinhilb, M.L., et al. 2001.J. Biol. Chem.276, 4476.
Meriin, A.B., et al. 1998.J. Biol. Chem. 273, 6373.
Adams, J., and Stein, R. 1996.Ann.Rep.Med. Chem.31, 279.
Klafki, H.W., et al. 1996.J. Biol. Chem.271, 2865.
Lee, D.H., and Goldberg, A.L., 1996.J. Biol. Chem.271, 27280.
Wiertz, E.J., et al. 1996.Cell84, 769.
Jensen, T.J., et al. 1995.Cell 83, 129.
Read, M.A., et al. 1995.
Cell 78, 761.

法律資訊

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

儲存類別代碼

11 - Combustible Solids

水污染物質分類(WGK)

WGK 3


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