跳转至内容
Merck
所有图片(1)

Key Documents

416154

Sigma-Aldrich

Isoginkgetin

≥98% (HPLC), solid, pre-mRNA splicing inhibitor, Calbiochem®

别名:

前体mRNA剪接抑制剂,异银杏双黄酮

登录查看公司和协议定价


About This Item

经验公式(希尔记法):
C32H22O10
CAS号:
分子量:
566.51
MDL號碼:
分類程式碼代碼:
12352200
NACRES:
NA.77

product name

前体mRNA剪接抑制剂,异银杏双黄酮, The Pre-mRNA Splicing Inhibitor, Isoginkgetin, also referenced under CAS 548-19-6, blocks the spliceosome-meidated splicing process.

品質等級

化驗

≥98% (HPLC)

形狀

solid

製造商/商標名

Calbiochem®

儲存條件

OK to freeze
protect from light

顏色

yellow

溶解度

DMSO: 100 mg/mL

運輸包裝

ambient

儲存溫度

2-8°C

InChI

1S/C32H22O10/c1-39-18-6-3-15(4-7-18)26-14-24(38)31-22(36)12-21(35)29(32(31)42-26)19-9-16(5-8-25(19)40-2)27-13-23(37)30-20(34)10-17(33)11-28(30)41-27/h3-14,33-36H,1-2H3

InChI 密鑰

HUOOMAOYXQFIDQ-UHFFFAOYSA-N

一般說明

一种细胞可渗透的,天然分离的银杏双黄酮类化合物,通过在前剪接体/A复杂阶段阻断对剪接体介导的剪接过程,作为一般的前mRNA剪接抑制剂(在使用HeLa核提取物的剪接测定中,ICmax = 50 µM)。已显示异银杏素治疗以可逆的方式导致HEK293衍生的培养物中的生长停滞,而不会影响细胞活率(33 µM持续24 h)。
天然分离的银杏双黄酮类化合物,通过阻止前剪接体A复合物募集U4/U5/U6 tri-snRNP(稳定的核RNA及其相关蛋白)形成B复合物,作为剪接体介导的前mRNA剪接的细胞可渗透,可逆抑制剂(在使用HeLa核提取物的剪接测定中,IC50和ICmax分别为30和50 µM)。已显示异银杏素治疗以可逆的方式导致HEK293衍生的培养物中的生长停滞,而不会影响细胞活率(33 µM持续24 h)。

包裝

用惰性气体包装

警告

毒性:标准处理(A)

其他說明

Kim, H.Y., et al. 2008.Arch.Pharm. Res.31, 265.
O′Brien, K., et al. 2008.J. Biol. Chem.283, 33147.
Yoon, S,O., et al. 2006.Mol.Cancer Ther.5, 2666.

法律資訊

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

儲存類別代碼

11 - Combustible Solids

水污染物質分類(WGK)

WGK 3

閃點(°F)

Not applicable

閃點(°C)

Not applicable


分析证书(COA)

输入产品批号来搜索 分析证书(COA) 。批号可以在产品标签上"批“ (Lot或Batch)字后找到。

已有该产品?

在文件库中查找您最近购买产品的文档。

访问文档库

Hyun Pyo Kim et al.
Archives of pharmacal research, 31(3), 265-273 (2008-04-15)
Biflavonoids belong to a subclass of the plant flavonoid family. Distribution of biflavonoids in the plant kingdom is limited to several species. Previously, some pharmacological activities of biflavonoids were described such as inhibition of histamine release from mast cells and
Kristine O'Brien et al.
The Journal of biological chemistry, 283(48), 33147-33154 (2008-10-02)
Membrane-permeable compounds that reversibly inhibit a particular step in gene expression are highly useful tools for cell biological and biochemical/structural studies. In comparison with other gene expression steps where multiple small molecule effectors are available, very few compounds have been
Sang-Oh Yoon et al.
Molecular cancer therapeutics, 5(11), 2666-2675 (2006-11-24)
Matrix metalloproteinase (MMP)-9 plays a key role in tumor invasion. Inhibitors of MMP-9 were screened from Metasequoia glyptostroboides (Dawn redwood) and one potent inhibitor, isoginkgetin, a biflavonoid, was identified. Noncytotoxic levels of isoginkgetin decreased MMP-9 production profoundly, but up-regulated the
Andrey A Parkhitko et al.
PLoS genetics, 17(2), e1009354-e1009354 (2021-02-17)
The RB1 tumor suppressor is recurrently mutated in a variety of cancers including retinoblastomas, small cell lung cancers, triple-negative breast cancers, prostate cancers, and osteosarcomas. Finding new synthetic lethal (SL) interactions with RB1 could lead to new approaches to treating

我们的科学家团队拥有各种研究领域经验,包括生命科学、材料科学、化学合成、色谱、分析及许多其他领域.

联系技术服务部门