推荐产品
生物源
mouse
品質等級
抗體表格
ascites fluid
抗體產品種類
primary antibodies
無性繁殖
nSyn12, monoclonal
物種活性
human
製造商／商標名
Upstate®
技術
immunohistochemistry: suitable
western blot: suitable
NCBI登錄號
運輸包裝
dry ice
基因資訊
human ... SNCA(6622)
特異性
α-在Tyr125和Tyr136硝化的突触核蛋白
β-在Tyr130硝化的突触核蛋白
β-在Tyr130硝化的突触核蛋白
應用
抗硝基α/β突触核蛋白抗体，克隆nSyn12是用于WB、IH的抗硝基α/β突触核蛋白抗体。
品質
对体外硝化的重组蛋白进行常规评估
標靶描述
α-突触核蛋白，Mr 14.5 kDa
β-突触核蛋白，Mr 17kDa
β-突触核蛋白，Mr 17kDa
外觀
形式：未纯化
法律資訊
UPSTATE is a registered trademark of Merck KGaA, Darmstadt, Germany
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儲存類別代碼
10 - Combustible liquids
水污染物質分類（WGK）
WGK 1
B I Giasson et al.
The Journal of biological chemistry, 274(12), 7619-7622 (1999-03-13)
alpha-Synuclein is a soluble presynaptic protein which is pathologically redistributed within intracellular lesions characteristic of several neurodegenerative diseases. Here we demonstrate that wild type and two mutant forms of alpha-synuclein linked to familial Parkinson's disease (Ala30 --> Pro and Ala53
Emilio Fernández-Espejo et al.
Antioxidants (Basel, Switzerland), 10(5) (2021-06-03)
Background. Salivary α-synuclein (aSyn) and its nitrated form, or 3-nitrotyrosine-α-synuclein (3-NT-αSyn), hold promise as biomarkers for idiopathic Parkinson's disease (IPD). Nitrative stress that is characterized by an excess of 3-nitrotyrosine proteins (3-NT-proteins) has been proposed as a pathogenic mechanism in
J M Souza et al.
The Journal of biological chemistry, 275(24), 18344-18349 (2000-04-05)
Intracellular proteinaceous aggregates are hallmarks of many common neurodegenerative disorders, and recent studies have shown that alpha-synuclein is a major component of several pathological intracellular inclusions, including Lewy bodies in Parkinson's disease (PD) and glial cell inclusions in multiple system
Nicole Willems et al.
BMC veterinary research, 12, 10-10 (2016-01-14)
Intervertebral disc (IVD) disease is a common spinal disorder in dogs and degeneration and inflammation are significant components of the pathological cascade. Only limited studies have studied the cytokine and chemokine profiles in IVD degeneration in dogs, and mainly focused
B I Giasson et al.
Science (New York, N.Y.), 290(5493), 985-989 (2000-11-04)
Aggregated alpha-synuclein proteins form brain lesions that are hallmarks of neurodegenerative synucleinopathies, and oxidative stress has been implicated in the pathogenesis of some of these disorders. Using antibodies to specific nitrated tyrosine residues in alpha-synuclein, we demonstrate extensive and widespread
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