260960

DNA-PK Inhibitor

The DNA-PK Inhibitor, also referenced under CAS 20357-25-9, controls the biological activity of DNA-PK. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylation applications.

• 别名: DNA-PK Inhibitor, DMNB, 4,5- Di methoxy-2- nitro benzaldehyde, DNA-Dependent Protein Kinase Inhibitor, DMNB, 4,5-Dimethoxy-2-nitrobenzaldehyde, DNA-Dependent Protein Kinase Inhibitor
• 经验公式（希尔记法）: C₉H₉NO₅
• CAS号: 20357-25-9
• 分子量: 211.17
• MDL號碼: MFCD00007134
• 分類程式碼代碼: 12352200

属性

• 品質等級: 100
• 化驗: ≥90% (GC)
• 形狀: solid
• 製造商／商標名: Calbiochem^®
• 儲存條件: OK to freeze; protect from light
• 顏色: bright yellow
• 溶解度: DMSO: 5 mg/mL
• 運輸包裝: ambient
• 儲存溫度: 2-8°C
• InChI: 1S/C9H9NO5/c1-14-8-3-6(5-11)7(10(12)13)4-9(8)15-2/h3-5H,1-2H3
• InChI 密鑰: YWSPWKXREVSQCA-UHFFFAOYSA-N

说明

一般說明

A cell-permeable vanillin derivative that acts as a potent and selective inhibitor of DNA-PK (DNA-dependent protein kinase) activity (IC₅₀ = 15 µM) and DNA-PK-mediated DSB (double strand break) DNA repair by NHEJ (non-homologous DNA-end-joining). Shown to effectively sensitize cells to killing by Cisplatin (Cat. No. 232120). Does not affect PKC or Chk2 kinase activities.

A cell-permeable vanillin derivative that acts as a potent and selective inhibitor of DNA-dependent protein kinase (DNA-PK) activity (IC₅₀ = 15 µM) and DNA-PK-mediated double strand break (DSB) DNA repair by non-homologous DNA-end-joining (NHEJ). Reported to effectively sensitize cells to Cisplatin (Cat. No. 232120). Does not affect the activities of PKC or Chk2.

生化／生理作用

Cell permeable: yes

Primary Target
DNA-PK activity

Product does not compete with ATP.

Reversible: no

Target IC₅₀: 15 µM against DNA-PK (DNA-dependent protein kinase) activity

包裝

Packaged under inert gas

警告

Toxicity: Carcinogenic / Teratogenic (D)

重構

Following reconstitution aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

其他說明

Willmore, E., et al. 2004. Blood,103, 4659.
Durant, S., and Karran, P. 2003. Nucleic Acids Res.31, 5501.

法律資訊

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

安全信息

• 儲存類別代碼: 11 - Combustible Solids
• 水污染物質分類（WGK）: WGK 3
• 閃點（°F）: Not applicable
• 閃點（°C）: Not applicable