推荐产品
product name
环己烯四醇 B 环氧化物, Conduritol B Epoxide, CAS 6090-95-5, is an irreversible Inhibitor of glucocerebrosidase in neurons. Also inhibits α-glucosidase activity in a variety of species.
品質等級
化驗
≥98% (HPLC)
形狀
solid
製造商／商標名
Calbiochem®
儲存條件
OK to freeze
desiccated
顏色
white
溶解度
DMSO: soluble
water: soluble
運輸包裝
ambient
儲存溫度
−20°C
InChI
1S/C6H10O5/c7-1-2(8)4(10)6-5(11-6)3(1)9/h1-10H/t1-,2-,3+,4+,5-,6+/m0/s1
InChI 密鑰
ZHMWOVGZCINIHW-FTYOSCRSSA-N
一般說明
抑制哺乳动物、蜗牛、甜杏仁和酵母中的 α-葡萄糖苷酶活性。是培养神经元过程中葡萄糖脑苷脂酶的不可逆、强效和特异性抑制剂。还有研究表明，还可抑制来自酵母和兔肠道蔗糖酶-异麦芽糖酶复合物的 α-葡萄糖苷酶。
生化／生理作用
主要靶标
α-葡萄糖苷酶
α-葡萄糖苷酶
产物不与ATP竞争。
可逆：否
细胞渗透性：否
警告
毒性：有害（C）
重構
溶液中不稳定；仅在使用前进行复溶。
其他說明
法律資訊
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
儲存類別代碼
11 - Combustible Solids
水污染物質分類（WGK）
WGK 3
閃點（°F）
Not applicable
閃點（°C）
Not applicable
Azucena Perez-Canamas et al.
Brain communications, 3(1), fcaa200-fcaa200 (2021-04-03)
TMEM106B is a transmembrane protein localized to the endo-lysosomal compartment. Genome-wide association studies have identified TMEM106B as a risk modifier of Alzheimer's disease and frontotemporal lobar degeneration, especially with progranulin haploinsufficiency. We recently demonstrated that TMEM106B loss rescues progranulin null
Electra Brunialti et al.
Journal of neuroinflammation, 18(1), 220-220 (2021-09-24)
Homozygotic mutations in the GBA gene cause Gaucher's disease; moreover, both patients and heterozygotic carriers have been associated with 20- to 30-fold increased risk of developing Parkinson's disease. In homozygosis, these mutations impair the activity of β-glucocerebrosidase, the enzyme encoded
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