219433

Cathepsin L Inhibitor IV

The Cathepsin L Inhibitor IV controls the biological activity of Cathepsin L. This small molecule/inhibitor is primarily used for Protease Inhibitors applications.

• 别名: Cathepsin L Inhibitor IV, 1-Naphthalenesulfonyl-IW-CHO
• 经验公式（希尔记法）: C₂₇H₂₉N₃O₄S
• 分子量: 491.60
• 分類程式碼代碼: 12352200
• NACRES: NA.77

属性

• 品質等級: 100
• 化驗: ≥98% (HPLC)
• 形狀: solid
• 製造商／商標名: Calbiochem^®
• 儲存條件: OK to freeze
• 顏色: white to off-white
• 溶解度: DMSO: 5 mg/mL
• 運輸包裝: ambient
• 儲存溫度: −20°C

说明

一般說明

A potent, cell-permeable, selective, and reversible inhibitor of cathepsin L (IC₅₀ = 1.9 nM). Also inhibits the release of Ca²⁺ and hydroxyproline from bone in an in vitro bone culture system and prevents bone loss in ovariectomized mice (~50 mg/kg).

A potent, cell-permeable, selective, and reversible inhibitor of cathepsin L (IC₅₀ = 1.9 nM). Inhibits the release of Ca²⁺ and hydroxyproline from bone in a bone culture system and prevents bone loss in ovariectomized mice (~50 mg/kg).

生化／生理作用

Cell permeable: yes

Primary Target
cathepsin L

Product does not compete with ATP.

Reversible: yes

Target IC₅₀: 1.9 nM against Cathepsin L

警告

Toxicity: Standard Handling (A)

序列

1-Naphthalenesulfonyl-Ile-Trp-CHO

重構

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

其他說明

Yasuma, T., et al. 1998. J. Med. Chem. 41, 4301.

法律資訊

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

安全信息

• 儲存類別代碼: 11 - Combustible Solids
• 水污染物質分類（WGK）: WGK 1
• 閃點（°F）: Not applicable
• 閃點（°C）: Not applicable