219404

Cathepsin H, Human Liver

Cathepsin H, Human Liver, CAS 60748-73-4, is native cathepsin H from human liver that functions both as an aminopeptidase and as an endopeptidase.

• 别名: Cathepsin H, Human Liver, CTSH, cat H, procathepsin h
• CAS号: 60748-73-4
• EC 号: 3.4.22.16 (BRENDA, IUBMB)
• 分類程式碼代碼: 12352202
• NACRES: NA.77

属性

• 品質等級: 100
• 形狀: liquid
• 比活性: ≥200 mU/mg protein
• 製造商／商標名: Calbiochem^®
• 儲存條件: OK to freeze; avoid repeated freeze/thaw cycles
• 技術: activity assay: suitable
• 顏色: colorless
• pH值: 4.5
• 溶解度: soluble; water: soluble
• 適合性: suitable for Western blot
• NCBI登錄號: NM_004390
• UniProt登錄號: P09668
• 運輸包裝: wet ice
• 儲存溫度: −70°C
• 基因資訊: human ... CTSH(1512)

说明

一般說明

Research area: Cell signaling

Native Cathepsin H, from the human liver, is the only cathepsin with mono-aminopeptidase activity.

應用

Cathepsin H has been used to determine the potential of aziridinyl peptides to act as inhibitors of this protein and potentially explore their therapeutic applications.

生化／生理作用

Cathepsin H, derived from human liver, serves dual functions as both an aminopeptidase and an endopeptidase. It plays a significant role in the catabolism of proteins within lysosomes. Cathepsin H is classified as an endoaminopeptidase because it can hydrolyze proteins, N-terminal substituted proteins, amino acid derivatives, and peptides with different chain lengths and N-terminal free amino acid derivatives. This protein is also observed to exhibit amidase and esterase activity.

包裝

Please refer to vial label for lot-specific concentration.

警告

Toxicity: Standard Handling (A)

單位定義

One unit is defined as the amount of enzyme that will hydrolyze 1.0 µmol H-Arg-βNA per min at 40°C, pH 6.8.

外觀

In 100 mM NaCl, 20 mM sodium acetate buffer, 1 mM EDTA, pH 4.5.

準備報告

Prepared from tissue of individuals that have been shown by certified tests to be negative for HBsAg and for antibodies to HIV and HCV.

重構

Following initial thaw, aliquot and freeze (-70°C).

其他說明

Note: 1 mU = 1 milliunit.

法律資訊

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

安全信息

• 儲存類別代碼: 12 - Non Combustible Liquids
• 水污染物質分類（WGK）: WGK 2