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Key Documents

204903

Sigma-Aldrich

抗补体5b-9 兔pAb

liquid, Calbiochem®

别名:

抗末端补体复合物,抗膜攻击复合物,抗MAC

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About This Item

分類程式碼代碼:
12352203
NACRES:
NA.43

生物源

rabbit

品質等級

抗體表格

purified antibody

抗體產品種類

primary antibodies

無性繁殖

polyclonal

形狀

liquid

包含

≤0.1% sodium azide as preservative

物種活性

human, mouse

製造商/商標名

Calbiochem®

儲存條件

OK to freeze
avoid repeated freeze/thaw cycles

同型

IgG

運輸包裝

wet ice

儲存溫度

−20°C

目標翻譯後修改

unmodified

一般說明

蛋白A纯化的兔多克隆抗体。识别C5b-C9 补体成分复合物。
识别补体成分复合物 Cb5-C9。
该抗补体5b-9兔pAb经验证可用于冷冻切片、免疫荧光、石蜡切片、径向免疫扩散以检测补体5b-9。

免疫原

纯化的人 SC5b-9 复合物

應用

冷冻切片(参见应用参考)

免疫荧光(参见注释)

石蜡切片(参见注释,需要加热预处理)

径向免疫扩散 (使用未稀释产品)

包裝

请参考特定浓度批号的标签。

警告

毒性:标准处理(A)

外觀

在PBS,pH 7.2中。

重構

初次解冻后,分装并冷冻保存(-20°C)。

其他說明

Schafer, H., et al. 1986.J. Immunol.137, 1945.
通过免疫扩散,该抗体对纯化形式或存在于眼镜蛇毒因子激活的人血清中的 C5b-9 复合物具有单特异性。与未活化的正常人血清或血浆没有反应性。据报道还用于免疫荧光。该抗体适用于福尔马林固定的石蜡切片; 抗原修复需要使用柠檬酸盐缓冲液和高压锅蒸煮1 分钟。在单个系统中,应对抗体进行滴定以获得最佳结果。

法律資訊

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

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儲存類別代碼

11 - Combustible Solids

水污染物質分類(WGK)

WGK 1

閃點(°F)

Not applicable

閃點(°C)

Not applicable


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E Panayiotou et al.
Biochemistry and biophysics reports, 8, 48-54 (2017-09-29)
Penetrance and age of onset of ATTRV30M amyloidotic neuropathy varies significantly among different populations. This variability has been attributed to both genetic and environmental modifiers. We studied the effect of genetic background on phenotype in two lines of transgenic mice
Elena Panayiotou et al.
PloS one, 12(4), e0175767-e0175767 (2017-04-14)
ATTRV30M amyloid neuropathy is a lethal autosomal dominant sensorimotor and autonomic neuropathy, caused by deposition of amyloid fibrils composed of aberrant transthyretin (TTR). Ages of onset and penetrance exhibit great variability and genetic factors have been implicated. Complement activation co-localizes
Jean F Regal et al.
Molecular immunology, 78, 38-47 (2016-09-03)
Preeclampsia is characterized by development of hypertension during pregnancy and reduced placental perfusion. Previous studies in a rat model of placental ischemia-induced hypertension demonstrated that inhibiting complement activation attenuated increased maternal blood pressure with C3a and C5a identified as the
Melina V Jones et al.
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To reduce immune-mediated damage in a rat model of neuromyelitis optica (NMO) by blocking neutrophil migration using SCH527123, a drug that inhibits CXCR2. Neuromyelitis optica is a relapsing autoimmune disease that preferentially targets the optic nerves and spinal cord leading
Ting-Ting Gao et al.
International journal of ophthalmology, 8(4), 675-680 (2015-08-27)
To investigate the expression of complement factors in the posterior scleral fibroblasts of guinea pigs with negative lens-defocused myopia. Eighteen guinea pigs were assigned randomly to two groups: the negative lens-defocused group (NLD group, n=9) and the normal control without

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