204863

Complement iC3b, Human

Complement iC3b, Human, is a native form that is formed by the cleavage of C3b by Factor I in the presence of Factor H, CR1, or membrane cofactor protein.

• 别名: Complement iC3b, Human Complement iC3b, Human iC3b
• 分類程式碼代碼: 12352202
• NACRES: NA.25

属性

• 品質等級: 100
• 化驗: ≥90% (SDS-PAGE)
• 形狀: liquid
• 不包含: preservative
• 製造商／商標名: Calbiochem^®
• 儲存條件: OK to freeze; avoid repeated freeze/thaw cycles
• 雜質: IgG, IgA, IgM, C5, Factor H, or Factor I, trace
• 運輸包裝: wet ice
• 儲存溫度: −70°C

说明

一般說明

Native, human iC3b complement component. iC3b is formed by the cleavage of C3b by Factor I in the presence of Factor H, CR1, or membrane cofactor protein. Factor I cleavage of C3b to iC3b inactivates and prevents C3b from functioning in the C3 or C5 convertase enzymes. The iC3b fragment thus produced is a glycoprotein composed of two C3α′ polypeptides of M.W. 43 kDa and M.W. 63 kDa which are disulfide bonded to the intact C3 β-chain (M.W. 75 kDa). iC3b interaction with CR3 (CD11b/CD18) receptors present on a variety of white blood cells greatly enhances phagocytosis of iC3b coated target cells or particles.

包裝

Please refer to vial label for lot-specific concentration.

警告

Toxicity: Standard Handling (A)

其他說明

Rosen, H. and Law, S.K.A. 1989. Curr. Top. Microbiol. Immunol.153, 99.
Ross, G.S. and Medof, M.E. 1985. Adv. Immunol.37, 217.

法律資訊

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

安全信息

• 儲存類別代碼: 10 - Combustible liquids
• 水污染物質分類（WGK）: WGK 1
• 閃點（°F）: Not applicable
• 閃點（°C）: Not applicable