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Merck
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Key Documents

203389

Sigma-Aldrich

Blebbistatin, Racemic

≥97% (HPLC), liquid, Myosin II inhibitor, Calbiochem®

别名:

InSolutionBlebbistatin, Racemic

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About This Item

经验公式（希尔记法）:
C18H16N2O2
分子量:
292.33
分類程式碼代碼:
12352200
NACRES:
NA.77

product name

Blebbistatin, Racemic, InSolution, ≥97%, 50 mM in 90% DMSO, reversible inhibitor of nonmuscle myosin II

品質等級

100

化驗

≥97% (HPLC)

形狀

liquid

製造商／商標名

Calbiochem®

儲存條件

OK to freeze
desiccated (hygroscopic)
protect from light

運輸包裝

wet ice

儲存溫度

−20°C

一般說明

A cell-permeable compound that acts as a selective, potent, and reversible inhibitor of non-muscle myosin II. Inhibits the ATPase and gliding motility of human platelets (≤100 µM) without affecting myosin light chain kinase (MLCK) activity. Has been shown to block cell blebbing and to rapidly disrupt directed cell migration and cytokinesis in vertebrate cells. Does not disrupt mitosis or affect contractile ring assembly.

生化／生理作用

Cell permeable: yes
Primary Target
ATPase
Product does not compete with ATP.
Reversible: yes
Target IC50: <100 µM inhibiting the ATPase and gliding motility of human platelets

包裝

Packaged under inert gas

警告

Toxicity: Harmful & Carcinogenic / Teratogenic (E)

外觀

A 50 mM (5 mg/342 µl) solution of (±)-Blebbistatin (Cat. No. 203390) in 90% DMSO.

重構

Following initial thaw, aliquot and freeze (-20°C).

其他說明

Shu, S., et al. 2005. Proc. Natl. Acad. Sci. USA102, 1472.
Kovacs, M., et al. 2004. J. Biol. Chem.279, 35557.
Straight, A.F., et al. 2003. Science299, 1743.
Cheung, A., et al. 2001. Mol. Biol. Cell Suppl.12, 271a.

法律資訊

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

儲存類別代碼

10 - Combustible liquids

水污染物質分類（WGK）

WGK 1

閃點（°F）

188.6 °F - closed cup - (Dimethylsulfoxide)

閃點（°C）

87 °C - closed cup - (Dimethylsulfoxide)

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