203291

Bisindolylmaleimide I, Hydrochloride

An enhanced water-soluble form of Bisindolylmaleimide I.

• 别名: Bisindolylmaleimide I, Hydrochloride, 2-[1-(3-Dimethylaminopropyl)-1H-indol-3-yl]-3-(1H-indol-3-yl)maleimide, HCl
• 经验公式（希尔记法）: C₂₅H₂₄N₄O₂ · xHCl
• CAS号: 176504-36-2
• 分子量: 412.48 (free base basis)
• MDL號碼: MFCD00236429
• 分類程式碼代碼: 12352111
• NACRES: NA.77

属性

• 品質等級: 100
• 化驗: ≥95% (HPLC)
• 形狀: solid
• 製造商／商標名: Calbiochem^®
• 儲存條件: OK to freeze
• 顏色: orange-red
• 溶解度: water: 10 mg/mL; DMSO: 20 mg/mL
• 運輸包裝: ambient
• 儲存溫度: 2-8°C
• InChI: 1S/C25H24N4O2.ClH/c1-28(2)12-7-13-29-15-19(17-9-4-6-11-21(17)29)23-22(24(30)27-25(23)31)18-14-26-20-10-5-3-8-16(18)20;/h3-6,8-11,14-15,26H,7,12-13H2,1-2H3,(H,27,30,31);1H
• InChI 密鑰: XRAMWNCMYJHGGH-UHFFFAOYSA-N

说明

一般說明

A reversible and ATP-competitive inhibitor of protein kinase C (K_i = 10 nM). Inhibits protein kinase A at much higher concentrations (K_i = 2 µM). An enhanced water soluble form of Bisindolylmaleimide I (Cat. No. 203290).

An enhanced water-soluble form of Bisindolylmaleimide I (Cat. No. 203290). A reversible and ATP-competitive inhibitor of protein kinase C (K_i = 10 nM). May inhibit protein kinase A at much higher concentrations (K_i = 2 µM).

生化／生理作用

Cell permeable: no

Primary Target
Protein kinase C

Product competes with ATP.

Reversible: yes

Target K_i: 10 nM against protein kinase C

警告

Toxicity: Standard Handling (A)

重構

Following reconstitution, store in the refrigerator (4°C). Stock solutions are stable for up to 6 months at 4°C.

其他說明

Le Panse, R., et al. 1994. Mol. Pharmacol.46, 445.
Kuchera, S., et al. 1993. Agents Actions 39, C169.
Wilkinson, S.E., et al. 1993. Biochem. J.294, 335.
Toullec, D., et al. 1991. J. Biol. Chem. 266, 15771.

法律資訊

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

安全信息

• 儲存類別代碼: 11 - Combustible Solids
• 水污染物質分類（WGK）: WGK 3
• 閃點（°F）: Not applicable
• 閃點（°C）: Not applicable