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一般說明
过氧亚硝酸盐(ONOO−)是一种强效氧化剂,由一氧化氮和超氧化物碰撞形成。
應用
过氧亚硝酸盐可用于诱导鼠大脑中的周细胞收缩。在免疫组织化学研究中,它已用于制备硝化蛋白标准品阳性对照。
生化/生理作用
过氧亚硝酸盐(ONOO−)具有杀菌活性。它促进细胞死亡,并有助于信号转导过程、线粒体功能和细胞凋亡途径。过氧亚硝酸盐的形成与各种疾病(包括血管疾病、缺血-再灌注损伤、循环休克、炎症、疼痛和神经退行性病变)的发展有关。
品質
通过处理未刺激的A431细胞进行常规评估。
外觀
0.3M NaOH
法律資訊
UPSTATE is a registered trademark of Merck KGaA, Darmstadt, Germany
訊號詞
Warning
危險聲明
危險分類
Eye Irrit. 2 - Met. Corr. 1 - Skin Irrit. 2
儲存類別代碼
8B - Non-combustible corrosive hazardous materials
水污染物質分類(WGK)
WGK 2
閃點(°F)
Not applicable
閃點(°C)
Not applicable
Nature reviews. Drug discovery, 6(8), 662-680 (2007-08-02)
Peroxynitrite--the product of the diffusion-controlled reaction of nitric oxide with superoxide radical--is a short-lived oxidant species that is a potent inducer of cell death. Conditions in which the reaction products of peroxynitrite have been detected and in which pharmacological inhibition
High-throughput, multiplexed analysis of 3-nitrotyrosine in individual proteins.
Current Protocols in Toxicology / Editorial Board, Mahin D. Maines (editor-in-chief) ... [Et al.] null
Pathological implications of nitric oxide, superoxide and peroxynitrite formation.
Biochemical Society Transactions, 21, 330-334 (1993)
Oxidative chemistry of peroxynitrite.
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The Journal of biological chemistry, 278(39), 37223-37230 (2003-07-15)
There is growing evidence that oxidative phosphorylation (OXPHOS) generates reactive oxygen and nitrogen species within mitochondria as unwanted byproducts that can damage OXPHOS enzymes with subsequent enhancement of free radical production. The accumulation of this oxidative damage to mitochondria in
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