推荐产品
产品名称
肌动蛋白相关蛋白2/3(Arp2/3)复合物抑制剂I, CK-666, Arp2/3 Complex Inhibitor I, CK-666, CAS 442633-00-3, is a cell-permeable selective inhibitor of actin assembly mediated by actin-related protein Arp2/3 complex (IC50 = 4 uM in human).
品質等級
化驗
≥95% (HPLC)
形狀
solid
製造商／商標名
Calbiochem®
儲存條件
OK to freeze
protect from light
顏色
off-white
溶解度
DMSO: 50 mg/mL
運輸包裝
ambient
儲存溫度
2-8°C
SMILES 字串
Fc1c(cccc1)C(=O)NCCc2c3c([nH]c2C)cccc3
InChI
1S/C18H17FN2O/c1-12-13(14-6-3-5-9-17(14)21-12)10-11-20-18(22)15-7-2-4-8-16(15)19/h2-9,21H,10-11H2,1H3,(H,20,22)
InChI 密鑰
UXRKUKRXVWJFER-UHFFFAOYSA-N
一般說明
一种可渗透细胞的吲哚基-氟苯甲酰胺化合物，可选择性抑制由人、牛、裂变酵母S. pombe和发芽酵母酿酒酵母起源的肌动蛋白相关蛋白Arp2/3复合物介导的肌动蛋白组装（IC50=4、17、5和12 µM），而不会影响粟酒裂殖酵母formin域Cdc12（FH2）介导的或自发的肌动蛋白聚合。显示以可逆的方式抑制感染的SKOV3细胞（IC50 = 7 µM）中细胞内李斯特菌周围肌动蛋白丝“彗星尾”的形成。结构研究表明，CK-666靶向Arp2的亚结构域4和Arp3的亚结构域1之间形成的口袋，从而防止Arp2/3在N-WASP-VCA结合后转变为活性构象。CK-666和CK-869（目录编号182516）表现出不同的结合方式，导致它们的酵母交叉反应性不同。CK-689（目录编号182517）可作为阴性对照。
包裝
用惰性气体包装
警告
毒性：监管审查（Z）
重構
复溶后，等分并冷冻保存（-20°C）。储备液在-20°C条件下可稳定保存6个月。
其他說明
Nolen, B.J., et al. 2009.Nature460, 1031.
法律資訊
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
儲存類別代碼
11 - Combustible Solids
水污染物質分類（WGK）
WGK 3
閃點（°F）
Not applicable
閃點（°C）
Not applicable
Binh An Truong Quang et al.
Nature communications, 12(1), 6511-6511 (2021-11-13)
In animal cells, shape is mostly determined by the actomyosin cortex, a thin cytoskeletal network underlying the plasma membrane. Myosin motors generate tension in the cortex, and tension gradients result in cellular deformations. As such, many cell morphogenesis studies have
Eoin McEvoy et al.
Nature communications, 13(1), 7089-7089 (2022-11-20)
The formation and recovery of gaps in the vascular endothelium governs a wide range of physiological and pathological phenomena, from angiogenesis to tumor cell extravasation. However, the interplay between the mechanical and signaling processes that drive dynamic behavior in vascular
Jia C Wang et al.
eLife, 11 (2022-04-12)
B-cell activation and immune synapse (IS) formation with membrane-bound antigens are actin-dependent processes that scale positively with the strength of antigen-induced signals. Importantly, ligating the B-cell integrin, LFA-1, with ICAM-1 promotes IS formation when antigen is limiting. Whether the actin
Daniel Blumenthal et al.
eLife, 9 (2020-07-29)
T cell activation by dendritic cells (DCs) involves forces exerted by the T cell actin cytoskeleton, which are opposed by the cortical cytoskeleton of the interacting antigen-presenting cell. During an immune response, DCs undergo a maturation process that optimizes their
Yilan Zhen et al.
Communications biology, 5(1), 511-511 (2022-06-01)
Oligodendrocyte progenitor cells (OPCs) express protocadherin 15 (Pcdh15), a member of the cadherin superfamily of transmembrane proteins. Little is known about the function of Pcdh15 in the central nervous system (CNS), however, Pcdh15 expression can predict glioma aggression and promote
我们的科学家团队拥有各种研究领域经验，包括生命科学、材料科学、化学合成、色谱、分析及许多其他领域.
联系技术服务部门