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COA分析证书/COQ

14-626-M

EGFR (L858R) Protein, active, 10 µg

Name: EGFR (L858R) Protein, active, 10 µg
Brand: MM

Active, N-terminal GST-tagged, recombinant human EGF Receptor, amino acids 696-end containing the mutation L858R, for use in Enzyme Assays.

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About This Item

分類程式碼代碼:

12352202

eCl@ss:

32160405

NACRES:

NA.32

生物源

human

品質等級

100

重組細胞

expressed in baculovirus infected Sf21 cells

分子量

M_w 85.8 kDa

製造商／商標名

Upstate^®

技術

activity assay: suitable

NCBI登錄號

NM_005228.3
NM_201282.1
NM_201283.1
NM_201284.1

UniProt登錄號

P00533

一般說明

N-terminal GST-tagged, recombinant human EGF Receptor, amino acids 696-end containing the mutation L858R

品質

routinely evaluated by phosphorylation of 0.1mg/ml Poly (Glu4-Tyr)

其他說明

For Specific Activity data, refer to the Certificate of Analysis for individual lots of this enzyme.

法律資訊

UPSTATE is a registered trademark of Merck KGaA, Darmstadt, Germany

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Activating mutations in the epidermal growth factor receptor underlying responsiveness of non-small-cell lung cancer to gefitinib.

Thomas J Lynch et al.

The New England journal of medicine, 350(21), 2129-2139 (2004-05-01)

Most patients with non-small-cell lung cancer have no response to the tyrosine kinase inhibitor gefitinib, which targets the epidermal growth factor receptor (EGFR). However, about 10 percent of patients have a rapid and often dramatic clinical response. The molecular mechanisms

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