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生物源
human
品質等級
重組細胞
expressed in baculovirus infected Sf21 cells
分子量
Mw 34.4 kDa (cdk5)
Mw 49.4 kDa (p25)
製造商/商標名
Upstate®
技術
activity assay: suitable (kinase)
NCBI登錄號
UniProt登錄號
一般說明
Complex of N-terminal His6-tagged, recombinant, full-length human cdk5 and Nterminal GST-tagged, recombinant, full-length human p25
Product Source: Co-expressed by baculovirus in Sf21 insect cells
應用
Research Category
Metabolism
Metabolism
Research Sub Category
Obesity
Metabolic Disorders
Obesity
Metabolic Disorders
生化/生理作用
Protein Target: CDK5/p25
Target Sub-Family: CMGC
包裝
Also available in 250 µg size --call for pricing and availability and reference catalog number 14-516M when ordering the 250 µg size.
品質
routinely evaluated by phosphorylation of Histone H1
外觀
Ni2+/NTA-agarose
儲存和穩定性
1 year at -70°C
其他說明
For Specific Activity data, refer to the Certificate of Analysis for individual lots of this enzyme.
法律資訊
UPSTATE is a registered trademark of Merck KGaA, Darmstadt, Germany
免責聲明
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
Cancer medicine, 10(11), 3689-3699 (2021-05-08)
The marked overexpression of cyclin-dependent kinase 5 (CDK5) or Notch1 receptor, which plays critical roles in pancreatic ductal adenocarcinoma (PDAC) development, has been detected in numerous PDAC cell lines and tissues. Although, a previous study has demonstrated that CDK5 inhibition
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